ReviewDental materials : official publication of the Academy of Dental Materials2017
Dentin on the nanoscale: Hierarchical organization, mechanical behavior and bioinspired engineering.
Review in Dental materials : official publication of the Academy of Dental Materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Organ-on-a-Chip Devices to Simulate the Dentin-Pulp Complex: A Qualitative Systematic Review.Annals of biomedical engineering · 2026Pooled it
- Dental Manifestations of Ehlers-Danlos Syndromes: A Systematic Review.Acta dermato-venereologica · 2020Pooled it
- Strategies to Microengineer Vascularized, Mineralized, and Immunomodulatory Niches for Dental Regeneration.Journal of endodontics · 2026Article
- A Biomimetic LiJournal of dental research · 2026Article
- Hydrogel microarchitecture as a regulatory cue for in vitro odontogenic differentiation.Journal of applied oral science : revista FOB · 2026Article
- Canonical and Noncanonical WNT-Loaded Hydrogel for Dentin-Pulp Regeneration.Journal of dental research · 2026Article
- Multifunctional bilayer scaffold for dental pulp protection and sustained calcium hydroxide release for mineralized tissue regeneration.Biomaterials · 2026Article
- Notum as a Crucial Regulator of Matrix Integrity in Dentinogenesis.Journal of cellular physiology · 2025Article
- Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.Journal of applied polymer science · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- Bioengineered Injectable Hydrogel Based on the Dentin Extracellular Matrix and Chitosan.ACS omega · 2025Article
- Nanostructural Analysis of Age-Related Changes Affecting Human Dentin.Calcified tissue international · 2025Article
- Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel.Biomaterials research · 2025Article
- Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Article
- Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.Dentistry journal · 2023Review
- Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth TransformerJournal of functional biomaterials · 2023Review
- Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases.Gels (Basel, Switzerland) · 2023Review
- Preparation of collagen fibrils from mineralized tissues and evaluation by atomic force microscopy.Journal of the mechanical behavior of biomedical materials · 2023Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
objectiveKnowledge of the structural organization and mechanical properties of dentin has expanded considerably during the past two decades, especially on a nanometer scale. In this paper, we review the recent literature on the nanostructural and nanomechanical properties of dentin, with special emphasis in its hierarchical organization.
methodsWe give particular attention to the recent literature concerning the structural and mechanical influence of collagen intrafibrillar and extrafibrillar mineral in healthy and remineralized tissues. The multilevel hierarchical structure of collagen, and the participation of non-collagenous proteins and proteoglycans in healthy and diseased dentin are also discussed. Furthermore, we provide a forward-looking perspective of emerging topics in biomaterials sciences, such as bioinspired materials design and fabrication, 3D bioprinting and microfabrication, and briefly discuss recent developments on the emerging field of organs-on-a-chip.
resultsThe existing literature suggests that both the inorganic and organic nanostructural components of the dentin matrix play a critical role in various mechanisms that influence tissue properties. SIGNIFICANCE: An in-depth understanding of such nanostructural and nanomechanical mechanisms can have a direct impact in our ability to evaluate and predict the efficacy of dental materials. This knowledge will pave the way for the development of improved dental materials and treatment strategies.
conclusionsDevelopment of future dental materials should take into consideration the intricate hierarchical organization of dentin, and pay particular attention to their complex interaction with the dentin matrix on a nanometer scale.
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Registered trials
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