ArticleCurrent biology : CB2017
Activation of a Plant NLR Complex through Heteromeric Association with an Autoimmune Risk Variant of Another NLR.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026Review
- Epidermal electronic-tattoo for plant immune response monitoring.Nature communications · 2025Article
- Graft incompatibility between pepper and tomato elicits an immune response and triggers localized cell death.Horticulture research · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
- Graft incompatibility between pepper and tomato can be attributed to genetic incompatibility between diverged immune systems.bioRxiv : the preprint server for biology · 2024Article
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- NLR receptors in plant immunity: making sense of the alphabet soup.EMBO reports · 2023Review
- Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificities.The Plant cell · 2023Article
- Broader functions of TIR domains in Arabidopsis immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana.PLoS genetics · 2023Article
- Structural mechanism of heavy metal-associated integrated domain engineering of paired nucleotide-binding and leucine-rich repeat proteins in rice.Frontiers in plant science · 2023Review
- The hybrid lethality of interspecific FMolecular breeding : new strategies in plant improvement · 2022Review
- Structural basis of NLR activation and innate immune signalling in plants.Immunogenetics · 2022Review
- Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair.eLife · 2021Article
- Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering.International journal of molecular sciences · 2021Review
- How activated NLRs induce anti-microbial defenses in plants.Biochemical Society transactions · 2021Review
- Plant "helper" immune receptors are CaScience (New York, N.Y.) · 2021Article
- Article
- The CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19.Plant biotechnology journal · 2021Article
- A New Catalog of Structural Variants in 1,301 A. thaliana Lines from Africa, Eurasia, and North America Reveals a Signature of Balancing Selection at Defense Response Genes.Molecular biology and evolution · 2021Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
When independently evolved immune receptor variants meet in hybrid plants, they can activate immune signaling in the absence of non-self recognition. Such autoimmune risk alleles have recurrently evolved at the DANGEROUS MIX2 (DM2) nucleotide-binding domain and leucine-rich repeat (NLR)-encoding locus in A. thaliana. One of these activates signaling in the presence of a particular variant encoded at another NLR locus, DM1. We show that the risk variants of DM1 and DM2d NLRs signal through the same pathway that is activated when plant NLRs recognize non-self elicitors. This requires the P loops of each protein and Toll/interleukin-1 receptor (TIR)-domain-mediated heteromeric association of DM1 and DM2d. DM1 and DM2d each resides in a multimeric complex in the absence of signaling, with the DM1 complex shifting to higher molecular weight when heteromerizing DM2 variants are present. The activation of the DM1 complex appears to be sensitive to the conformation of the heteromerizing DM2 variant. Autoimmunity triggered by interaction of this NLR pair thus suggests that activity of heteromeric NLR signaling complexes depends on the sum of activation potentials of partner NLRs.
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