Evidence map›Paper›PMID 28416012›Full record

ReviewItalian journal of pediatrics2017

Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.

Concetta Marsico, David W Kimberlin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 269 citations in OpenAlex.

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  20. Quantitative measures of humanPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Concetta MarsicoDepartment of Medical and Surgical Sciences, Neonatology and Neonatal Intensive Care Unit, St.Orsola-Malpighi Hospital, University of Bologna, via Massarenti 11, 40138, Bologna, Italy. conce.marsico@gmail.com.ORCID http://orcid.org/0000-0001-5258-9417
David W KimberlinDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Children's Harbor Building 303, 1600 7th Avenue South, Birmingham, AL, 35233, USA.
Children's of Alabama · USIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · IT

Funding

CLINICAL TRIALS FOR ANTIVIRAL THERAPIES-266030025-266030025N01AI030025 · NIAID · UNIVERSITY OF ALABAMA BIRMINGH · PI WHITLEY, RICHARD R · 2003 to 2006
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NIAID NIH HHS HHSN272201000017CNIAID NIH HHS HHSN272201100035CNIAID NIH HHS HHSN272201600001CNIAID NIH HHS HHSN272201600001GNIAID NIH HHS HHSN272201600007CNIAID NIH HHS HHSN272201600017CNIAID NIH HHS N01 AI030025
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is the most frequent cause of congenital infection worldwide, with an estimated incidence in developing countries of 0.6-0.7% of all live births. The burden of disease related to congenital CMV in substantial, as it is the leading non-genetic cause of sensorineural hearing loss and an important cause of neurodevelopmental disabilities in children. Despite its clinical significance, congenital CMV infection often goes undetected because the majority of infected infants are asymptomatic at birth and screening programs have not been substantially implemented. Other than behavioral measures, effective interventions aimed at the prevention of maternal infection and of mother-to-child transmission are lacking. Due to a convergence of recent advances in both diagnostic and therapeutic strategies in infants with congenital CMV, though, the field likely will be changing rapidly over just the next few years. Specifically, a highly-sensitive screening test with high throughput potential has been developed, and treatment of infants symptomatically infected with congenital CMV has proven to be well-tolerated and effective in improving long-term hearing and neurodevelopmental outcomes.This review highlights the clinical importance of congenital CMV infection, the developments in laboratory diagnostics, and the benefits of antiviral therapy. It also identifies the global efforts still required in the prevention of maternal infection and in the optimization of antiviral therapy to further reduce the burden of congenital CMV disease.

Indexed as

Antiviral AgentsCytomegalovirusCytomegalovirus InfectionsDeveloping CountriesEarly DiagnosisFemaleHumansIncidenceInfantInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousRisk AssessmentSeverity of Illness IndexAntiviral AgentsAntiviral therapyCongenital cytomegalovirusHearing lossMother-to-child transmissionNeonatal screening

Identifiers

PMID28416012
PMCPMC5393008
OpenAlexW2607437541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.