ArticleOncotarget2017
Hypoxia-inducible factor 1a induces phenotype switch of human aortic vascular smooth muscle cell through PI3K/AKT/AEG-1 signaling.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Identification of hub genes in aortic dissection based on weighted gene co-expression network analysis and Mendelian randomization study.Journal of cardiothoracic surgery · 2025Article
- Analysis of serum levels of HIF-1α and IL-6 in patients with acute stanford type a aortic dissection.Journal of cardiothoracic surgery · 2025Article
- LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2/STAT3 signaling pathway.Scientific reports · 2024Article
- Spaceflight effects on human vascular smooth muscle cell phenotype and function.NPJ microgravity · 2024Article
- Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease.Frontiers in pharmacology · 2024Review
- Article
- Reoxygenation Modulates the Adverse Effects of Hypoxia on Wound Repair.International journal of molecular sciences · 2022Article
- Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1.Calcified tissue international · 2022Article
- Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation.Cellular and molecular life sciences : CMLS · 2022Article
- The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.European journal of clinical investigation · 2022Review
- Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall.Clinical science (London, England : 1979) · 2022Review
- Long non-coding RNA HIF1A-AS2 modulates the proliferation, migration, and phenotypic switch of aortic smooth muscle cells in aortic dissection via sponging microRNA-33b.Bioengineered · 2022Article
- Hypoxia Marker Carbonic Anhydrase IX Is Present in Abdominal Aortic Aneurysm Tissue and Plasma.International journal of molecular sciences · 2022Article
- Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility.JCI insight · 2021Article
- Non-syndromic thoracic aortic aneurysm: cellular and molecular insights.The Journal of pathology · 2021Review
- The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives.Cell & bioscience · 2021Review
- Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis.Molecular aspects of medicine · 2021Article
- Photo-functionalized TiOBioactive materials · 2021Article
- Non-coding RNAs in aortic dissection: From biomarkers to therapeutic targets.Journal of cellular and molecular medicine · 2020Review
- Differential expression of miRNAs in skeletal muscles of Indian sheep with diverse carcass and muscle traits.Scientific reports · 2020Article
Corrections and comments
- Retraction · 2024-06-20Duplication of/in Image · Investigation by Third Party · · see also: https://pubpeer.com/publications/EB14010A8B0D06AE44680EAB5980D7
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, hypoxia-inducible factor 1a (HIF-1a) and astrocyte elevated gene-1 (AEG-1) have been involved in the proliferation, migration and morphological changes of vascular smooth muscle cells. However, the potential relationship of HIF-1a-AEG-1 pathway in human aortic smooth muscle cell (HASMC) has not been reported. In the present study, in-vitro assays were utilized to explore the potential impact of HIF-1a-AEG-1 signaling on HASMC phenotype. Here, we found that HIF-1a expression was up-regulated in the media of thoracic aortic dissection tissues as compared with normal aortic tissues, and was associated with increased apoptotic SMCs and decreased AEG-1 expression. Mechanically, hypoxia promoted the expression of HIF-1a by PI3K-AKT pathway in HASMCs; HIF-1a further suppressed the expressions of AEG-1, a-SMA and SM22a, and promoted osteopontin (OPN) expression. Functionally, HIF-1a inhibited the proliferation and migration of HASMCs. However, si-HIF-1a or Akt inhibitor abrogated HIF-1a-mediated related expressions and biological effects above. In conclusion, HIF-1a induces HASMC phenotype switch, and closely related to PI3K/AKT and AEG-1 signaling, which may provide new avenues for the prevention and treatment of aortic dissection diseases.
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