ArticleOncotarget2017
Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Regulatory roles of circular RNAs in poultry diseases: mechanisms and research advances.Frontiers in veterinary science · 2025Review
- Avian Leukosis: Will We Be Able to Get Rid of It?Animals : an open access journal from MDPI · 2023Review
- Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.Frontiers in veterinary science · 2023Article
- Advances on genetic and genomic studies of ALV resistance.Journal of animal science and biotechnology · 2022Review
- Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.Veterinary research · 2022Article
- Genome-wide identification and functional analysis of circRNAs in Trichophyton rubrum conidial and mycelial stages.BMC genomics · 2022Article
- Genetic resilience in chickens against bacterial, viral and protozoal pathogens.Frontiers in veterinary science · 2022Review
- Viruses join the circular RNA world.The FEBS journal · 2021Review
- Comprehensive profiling analysis of the N6-methyladenosine-modified circular RNA transcriptome in cultured cells infected with Marek's disease virus.Scientific reports · 2021Article
- Article
- The role of circular RNAs in viral infection and related diseases.Virus research · 2021Review
- Differential DNA Methylation and Gene Expression Between ALV-J-Positive and ALV-J-Negative Chickens.Frontiers in veterinary science · 2021Article
- Data Mining Identifies Differentially Expressed Circular RNAs in Skeletal Muscle of Thermally Challenged Turkey Poults.Frontiers in physiology · 2021Article
- The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.RNA biology · 2021Review
- Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.Emerging microbes & infections · 2020Article
- Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System.Life (Basel, Switzerland) · 2020Review
- Transcriptome Analysis of circRNA and mRNA in Theca Cells during Follicular Development in Chickens.Genes · 2020Article
- Genome-wide analysis of circular RNAs involved in Marek's disease tumourigenesis in chickens.RNA biology · 2020Article
- Identification of circRNAs in the Liver of Whitespotted Bamboo Shark (Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian leukosis virus subgroup (ALV-J) is an oncogenic neoplasm-inducing retrovirus that causes significant economic losses in the poultry industry. Recent studies have demonstrated circular RNAs (circRNAs) are implicated in pathogenic processes; however, no research has indicated circRNAs are involved in resistance to disease. In this study, over 1800 circRNAs were detected by circRNA sequencing of liver tissues from ALV-J-resistant (n = 3) and ALV-J-susceptible chickens (n = 3). 32 differentially expressed circRNAs were selected for analyzing including 12 upregulated in ALV-J-resistant chickens and 20 upregulated in ALV-J-susceptible chickens, besides, the top five microRNAs (miRNAs) for 12 upregulated circRNAs in ALV-J-resistant chickens were analyzed. Gene ontology and KEGG pathway analyses were performed for miRNA target genes, the predicted genes were mainly involved in immune pathways. This study provides the first evidence that circRNA alterations are involved in resistance to ALV-J-induced tumor formation. We propose circRNAs may help to mediate tumor induction and development in chickens.
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