ArticleOncotarget2017
18F-Fluoride PET/CT tumor burden quantification predicts survival in breast cancer.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Full-Body Tumor Response Heterogeneity of Metastatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radiopharmaceutical Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Association of tumor markers CA 15-3, CEA, and CA 125 with [Frontiers in oncology · 2025Article
- Estimating normal metabolic activity for disease quantification via PET/CT images.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Early SUVQuantitative imaging in medicine and surgery · 2021Article
- Comparison ofEuropean journal of nuclear medicine and molecular imaging · 2020Article
- Article
- Hospice Admission and Survival AfterJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Site specific measurements of bone formation using [Quantitative imaging in medicine and surgery · 2018Review
- Therapy assessment of bone metastatic disease in the era ofEuropean journal of nuclear medicine and molecular imaging · 2017Review
- Is interimRadiologia brasileiraArticle
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Authors and funding
11 authors.
Funding
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Abstract
purposeIn bone-metastatic breast cancer patients, there are no current imaging biomarkers to identify which patients have worst prognosis. The purpose of our study was to investigate if skeletal tumor burden determined by 18F-Fluoride PET/CT correlates with clinical outcomes and may help define prognosis throughout the course of the disease.
resultsBone metastases were present in 49 patients. On multivariable analysis, skeletal tumor burden was significantly and independently associated with overall survival (p < 0.0001) and progression free-survival (p < 0.0001). The simple presence of bone metastases was associated with time to bone event (p = 0.0448). MATERIALS AND
methodsWe quantified the skeletal tumor burden on 18F-Fluoride PET/CT images of 107 female breast cancer patients (40 for primary staging and the remainder for restaging after therapy). Clinical parameters, primary tumor characteristics and skeletal tumor burden were correlated to overall survival, progression free-survival and time to bone event. The median follow-up time was 19.5 months.
conclusions18F-Fluoride PET/CT skeletal tumor burden is a strong independent prognostic imaging biomarker in breast cancer patients.
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