ArticleJournal of pathology and translational medicine2017
Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center.
Article in Journal of pathology and translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Inflammatory myofibroblastic tumor masquerading as carcinoma.Radiology case reports · 2026Article
- Clinicopathologic spectrum and diagnostic strategies of intrahepatic neoplasms with prominent inflammatory background.Virchows Archiv : an international journal of pathology · 2026Article
- Management of Inflammatory Myofibroblastic Tumor of Urinary Bladder With Partial Cystectomy: A Case Report.Cureus · 2026Article
- Inflammatory Myofibroblastic Tumour of the Bladder in a Young Male: A Rare Case Report.Cureus · 2025Article
- Inflammatory Myofibroblastic Tumor: An Updated Review.Cancers · 2025Review
- Clinicopathological Features and Immunochemical Staining of Inflammatory Myofibroblastic Tumor: A Retrospective Study of 48 Cases.Analytical cellular pathology (Amsterdam) · 2025Article
- Inflammatory myofibroblastic tumor in the liver after bone marrow transplantation: case report and literature review.Frontiers in medicine · 2025Article
- Inflammatory myofibroblastic tumor in the urinary bladder in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Inflammatory myofibroblastic tumor of the bladder: Computed tomographic features.Molecular and clinical oncology · 2023Article
- Case report: Epithelioid inflammatory myofibroblastic sarcoma treated with an ALK TKI ensartinib.Frontiers in oncology · 2023Article
- Child inflammatory myofibroblastic tumor of the kidney misdiagnosed as Wilms' tumor: case report.Radiology case reports · 2022Article
- Inflammatory Myofibroblastic Tumour of the Sinonasal Tract with Orbital and Intracranial Extensions Simulating a Malignancy: A Case Report and Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- An extremely rare case of malignant jejunal mesenteric inflammatory myofibroblastic tumor in a 61-year-old male patient: A case report and literature review.Frontiers in medicine · 2022Article
- Case Report: Early Distant Metastatic Inflammatory Myofibroblastic Tumor HarboringFrontiers in medicine · 2022Article
- Complicated course of biliary inflammatory myofibroblastic tumor mimicking hilar cholangiocarcinoma: A case report and literature review.World journal of clinical cases · 2021Article
- Epithelioid Inflammatory Myofibroblastic Sarcoma Presenting as Gastrointestinal Bleed: Case Report and Literature Review.JPGN reports · 2021Review
- Primary inflammatory myofibroblastic tumor of stomach-report of a very rare case.Journal of family medicine and primary care · 2021Article
- Successful treatment of pulmonary inflammatory myofibroblastic tumor with platinum-pemetrexed: The first report of two cases.Thoracic cancer · 2020Article
- Rare presentation of inflammatory myofibroblastic tumor in the kidney.Radiology case reports · 2020Article
- Histopathological landscape of rare oesophageal neoplasms.World journal of gastroenterology · 2020Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. According to World Health Organization (WHO) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential for recurrence and rare metastasis. There are no definite histopathologic, molecular, or cytogenetic features to predict malignant transformation, recurrence, or metastasis.
methodsA 5-year retrospective study of histopathologically diagnosed inflammatory myofibroblastic tumors of various anatomic sites was conducted to correlate anaplastic lymphoma kinase-1 (ALK-1) expression with histological atypia, multicentric origin of tumor, recurrence, and metastasis. Clinical details of all the cases were noted from the clinical work station. Immunohistochemical stains for ALK-1 and other antibodies were performed. Statistical analysis was done using Fisher exact test.
resultsA total of 18 cases of inflammatory myofibroblastic tumors were found during the study period, of which 14 were classical. The female-male ratio was 1:1 and the mean age was 23.8 years. Histologically atypical (four cases) and multifocal tumors (three cases, multicentric in origin) were noted. Recurrence was noted in 30% of ALK-1 positive and 37.5% of ALK-1 negative cases, whereas metastasis to the lung, liver, and pelvic bone was noted in the ALK-1 positive group only.
conclusionsOverall, ALK-1 protein was expressed in 55.6% of inflammatory myofibroblastic tumors. There was no statistically significant correlation between ALK-1 expression, tumor type, recurrence and metastasis. However, ALK-1 immunohistochemistry is a useful diagnostic aid in the appropriate clinical and histomorphologic context.
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