ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017
Death Within 1 Month of Diagnosis in Childhood Cancer: An Analysis of Risk Factors and Scope of the Problem.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Treatment-related mortality in children with cancer in low-income and middle-income countries: a systematic review and meta-analysis.The Lancet. Oncology · 2023Pooled it
- Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.European journal of cancer (Oxford, England : 1990) · 2022Pooled it
- Racial and ethnic disparities among children with primary central nervous system tumors in the US.Journal of neuro-oncology · 2021Pooled it
- Hospital contacts before childhood cancer and the risk of early mortality: a Danish and Swedish population-based cohort study.British journal of cancer · 2026Article
- Article
- Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia.Cancers · 2025Article
- The impact of environmental contaminants, air pollution, and social deprivation on childhood leukemia survival in California.Frontiers in oncology · 2025Article
- Treatment-related mortality among children with cancer in Denmark during 2001-2021.Acta oncologica (Stockholm, Sweden) · 2024Article
- Pre- and Postnatal Exposures to Tobacco Smoking and Survival of Childhood Acute Lymphoblastic and Myeloid Leukemias in California, United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Article
- N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis.International journal of biological sciences · 2024Article
- Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia.Pediatric blood & cancer · 2024Article
- Cancer mortality in childhood and adolescence: analysis of trends and spatial distribution in the 133 intermediate Brazilian regions grouped by macroregions.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Article
- Disparities in Neuro-Oncology.Current neurology and neuroscience reports · 2023Review
- Factors Improving Oncology Nurse Role Performance in Providing Pediatric Palliative Care: A SWOT Analysis.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Early death from childhood cancer: First medical record-level analysis reveals insights on diagnostic timing and cause of death.Cancer medicine · 2023Article
- In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study.Cancers · 2023Article
- Ethnic disparities in childhood leukemia survival by border residence: A Texas population-based analysis.Cancer · 2023Article
- Risk of early death in adolescents and young adults with cancer: a population-based study.Journal of the National Cancer Institute · 2023Article
- Long-Term Survival of Neuroblastoma Patients Receiving Surgery, Chemotherapy, and Radiotherapy: A Propensity Score Matching Study.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purpose Despite advances in childhood cancer care, some patients die soon after diagnosis. This population is not well described and may be under-reported. Better understanding of risk factors for early death and scope of the problem could lead to prevention of these occurrences and thus better survival rates in childhood cancer. Methods We retrieved data from SEER 13 registries on 36,337 patients age 0 to 19 years diagnosed with cancer between 1992 and 2011. Early death was defined as death within 1 month of diagnosis. Socioeconomic status data for each individual's county of residence were derived from Census 2000. Crude and adjusted odds ratios and corresponding 95% CIs were estimated for the association between early death and demographic, clinical, and socioeconomic factors. Results Percentage of early death in the period was 1.5% (n = 555). Children with acute myeloid leukemia, infant acute lymphoblastic leukemia, hepatoblastoma, and malignant brain tumors had the highest risk of early death. On multivariable analysis, an age younger than 1 year was a strong predictor of early death in all disease groups examined. Black race and Hispanic ethnicity were both risk factors for early death in multiple disease groups. Residence in counties with lower than median average income was associated with a higher risk of early death in hematologic malignancies. Percentages of early death decreased significantly over time, especially in hematologic malignancies. Conclusion Risk factors for early death in childhood cancer include an age younger than 1 year, specific diagnoses, minority race and ethnicity, and disadvantaged socioeconomic status. The population-based disease-specific percentages of early death were uniformly higher than those reported in cooperative clinical trials, suggesting that early death is under-reported in the medical literature. Initiatives to identify those at risk and develop preventive interventions should be prioritized.
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