ArticlePLoS genetics2017
Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Intestinal obstruction impairs feeding and promotes sleep inScience advances · 2026Article
- A brain-specific microRNA,Genes & development · 2026Article
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- Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila.Current opinion in neurobiology · 2025Review
- 40 years of homeodomain transcription factors in the Drosophila nervous system.Development (Cambridge, England) · 2024Review
- Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression.Developmental neurobiology · 2022Article
- Integration of Spatial and Temporal Patterning in the Invertebrate and Vertebrate Nervous System.Frontiers in neuroscience · 2022Review
- Article
- Article
- Specification of Drosophila neuropeptidergic neurons by the splicing component brr2.PLoS genetics · 2018Article
- Dynamics of transcriptional (re)-programming of syncytial nuclei in developing muscles.BMC biology · 2017Article
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extensive genetic regulatory flows underlying specification of different neuronal subtypes are not well understood at the molecular level. The Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues; the Hox homeotic network and GATA factor grn, and temporal cues; the hb -> Kr -> Pdm -> cas -> grh temporal cascade. These spatio-temporal cues combine into two distinct codes; one for Tv1 and one for dAp neurons that activate a common terminal selector feedforward cascade of col -> ap/eya -> dimm -> Nplp1. Here, we molecularly decode the specification of Nplp1 neurons, and find that the cis-regulatory organization of col functions as an integratory node for the different spatio-temporal combinatorial codes. These findings may provide a logical framework for addressing spatio-temporal control of neuronal sub-type specification in other systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.