ArticlePLoS neglected tropical diseases2017
Knockdown resistance mutations predict DDT resistance and pyrethroid tolerance in the visceral leishmaniasis vector Phlebotomus argentipes.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Larval habitat drives differential selection pressures on genetic insecticide resistance and metabolic enzyme plasticity in Anopheles gambiae s.l during laboratory colonization.Scientific reports · 2026Article
- Presence of localized elevated metabolic enzymes and kdr mutations in the voltage-gated sodium channel gene indicate early evidence of resistance of Phlebotomus argentipes to alpha-cypermethrin in Bihar, India.Parasites & vectors · 2026Article
- Article
- Monitoring alpha-cypermethrin susceptibility of Phlebotomus argentipes, the vector of visceral leishmaniasis in India, using the CDC bottle bioassay.Parasites & vectors · 2024Article
- Review
- Development and application of species ID and insecticide resistance assays, for monitoring sand fly Leishmania vectors in the Mediterranean basin and in the Middle East.PLoS neglected tropical diseases · 2024Article
- Sergentomyia khawi: a potential vector for Leishmania and Trypanosoma parasites affecting humans and animals and insecticide resistance status in endemic areas of Songkhla, southern Thailand.Parasites & vectors · 2024Article
- Knockdown resistance mutations in Phlebotomus argentipes sand flies in Bihar, India.Parasites & vectors · 2024Article
- Molecular surveillance of insecticide resistance in Phlebotomus argentipes targeted by indoor residual spraying for visceral leishmaniasis elimination in India.PLoS neglected tropical diseases · 2023Article
- Article
- Characterization of the glutathione S-transferase genes in the sand flies Phlebotomus papatasi and Lutzomyia longipalpis shows expansion of the novel glutathione S-transferase xi (X) class.Insect molecular biology · 2022Article
- Susceptibility status of the wild-caught Phlebotomus argentipes (Diptera: Psychodidae: Phlebotominae), the sand fly vector of visceral leishmaniasis, to different insecticides in Nepal.PLoS neglected tropical diseases · 2022Article
- Population genetic structure and evolutionary genetics of Anopheles sinensis based on knockdown resistance (kdr) mutations and mtDNA-COII gene in China-Laos, Thailand-Laos, and Cambodia-Laos borders.Parasites & vectors · 2022Article
- Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.Parasites & vectors · 2022Review
- Impact of IRS: Four-years of entomological surveillance of the Indian Visceral Leishmaniases elimination programme.PLoS neglected tropical diseases · 2021Article
- Chemical control and insecticide resistance status of sand fly vectors worldwide.PLoS neglected tropical diseases · 2021Review
- Ultrastructure of the Antennae and Sensilla of Nyssomyia intermedia (Diptera: Psychodidae), Vector of American Cutaneous Leishmaniasis.Journal of medical entomology · 2020Article
- Insecticide susceptibility of the sand fly leishmaniasis vector Phlebotomus argentipes in Sri Lanka.Parasites & vectors · 2020Article
- Population dynamics, pathogen detection and insecticide resistance of mosquito and sand fly in refugee camps, Greece.Infectious diseases of poverty · 2020Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIndoor residual spraying (IRS) with DDT has been the primary strategy for control of the visceral leishmaniasis (VL) vector Phlebotomus argentipes in India but efficacy may be compromised by resistance. Synthetic pyrethroids are now being introduced for IRS, but with a shared target site, the para voltage-gated sodium channel (VGSC), mutations affecting both insecticide classes could provide cross-resistance and represent a threat to sustainable IRS-based disease control. METHODOLOGY/PRINCIPAL
findingsA region of the Vgsc gene was sequenced in P. argentipes from the VL hotspot of Bihar, India. Two knockdown resistance (kdr) mutations were detected at codon 1014 (L1014F and L1014S), each common in mosquitoes, but previously unknown in phlebotomines. Both kdr mutations appear largely recessive, but as homozygotes (especially 1014F/F) or as 1014F/S heterozygotes exert a strong effect on DDT resistance, and significantly predict survivorship to class II pyrethroids in short-duration bioassays. The mutations are present at high frequency in wild P. argentipes populations from Bihar, with 1014F significantly more common in higher VL areas. CONCLUSIONS/SIGNIFICANCE: The Vgsc mutations detected appear to be a primary mechanism underlying DDT resistance in P. argentipes and a contributory factor in reduced pyrethroid susceptibility, suggesting a potential impact if P. argentipes are subjected to suboptimal levels of pyrethroid exposure, or additional resistance mechanisms evolve. The assays to detect kdr frequency changes provide a sensitive, high-throughput monitoring tool to detecting spatial and temporal variation in resistance in P. argentipes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.