ArticlePloS one2017
An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- In vitro probiotic potential of lactic acid bacteria isolated from the intestines of Muscovy ducks.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
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- Genomic andFrontiers in microbiology · 2023Article
- LrpCBA pilus proteins of gut-dwelling Ligilactobacillus ruminis: crystallization and X-ray diffraction analysis.Acta crystallographica. Section F, Structural biology communications · 2021Article
- Comparative Genomics of 42Antibiotics (Basel, Switzerland) · 2021Article
- Complete Genome Sequencing and Comparative Genomics of Three Potential Probiotic Strains,Frontiers in microbiology · 2021Article
- Comparative Genomics Analysis ofGenes · 2020Article
- Article
- From Microbial Genomics to Metagenomics.International journal of genomics · 2020Article
- Comparative genome analysis ofMicrobial genomics · 2019Article
- Novel Molecular Insights about Lactobacillar Sortase-Dependent Piliation.International journal of molecular sciences · 2017Review
- A Comparative Characterization of Different Host-sourcedFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As an ecological niche, the mammalian intestine provides the ideal habitat for a variety of bacterial microorganisms. Purportedly, some commensal genera and species offer a beneficial mix of metabolic, protective, and structural processes that help sustain the natural digestive health of the host. Among these sort of gut inhabitants is the Gram-positive lactic acid bacterium Lactobacillus ruminis, a strict anaerobe with both pili and flagella on its cell surface, but also known for being autochthonous (indigenous) to the intestinal environment. Given that the molecular basis of gut autochthony for this species is largely unexplored and unknown, we undertook a study at the genome level to pinpoint some of the adaptive traits behind its colonization behavior. In our pan-genomic probe of L. ruminis, the genomes of nine different strains isolated from human, bovine, porcine, and equine host guts were compiled and compared for in silico analysis. For this, we conducted a geno-phenotypic assessment of protein-coding genes, with an emphasis on those products involved with cell-surface morphology and anaerobic fermentation and respiration. We also categorized and examined the core and accessory genes that define the L. ruminis species and its strains. Here, we made an attempt to identify those genes having ecologically relevant phenotypes that might support or bring about intestinal indigenousness.
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