Evidence map›Paper›PMID 28414728›Full record

Trial reportPloS one2017

Clown-care reduces pain in children with cerebral palsy undergoing recurrent botulinum toxin injections- A quasi-randomized controlled crossover study.

Hilla Ben-Pazi, Avraham Cohen, Naama Kroyzer, Renana Lotem-Ophir, Yaakov Shvili, Gidon Winter, Lisa Deutsch, Yehuda Pollak

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01377883 nacompletednot on this map

Clown Care for Botulinum Toxin (BTX)

TypeinterventionalSponsorShaare Zedek Medical CenterRan2010 to 2011Enrolled25ConditionsCerebral Palsy, PainArmsstandard, clown care
NCT05257096 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Can Medical Clowns Prevent the Usage of Sedation During the Performance of EEG in Young Children

TypeinterventionalSponsorBnai Zion Medical CenterRan2019 to 2022Enrolled100ConditionsEEG With Periodic Abnormalities, Child, OnlyArmsMedical clown
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  2. Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hilla Ben-PaziNeuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Avraham CohenDepartment of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
Naama KroyzerNeuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Renana Lotem-OphirDepartment of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
Yaakov ShviliDepartment of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
Gidon WinterNeuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Lisa DeutschBiostatistical Consulting (L.D), BioStats, Modien, Israel.
Yehuda PollakSchool of Education, The Hebrew University of Jerusalem, Jerusalem, Israel.
Shaare Zedek Medical Center · ILHebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe investigated the impact of clown-care on pain in 45 children with cerebral palsy who underwent recurrent Botulinum-toxin injections (age 7.04± 4.68 years). Participants were randomized to receive either clown (n = 20) or standard (n = 25) -care.

methodsPain Visual-Analogue-Scale (range 1-5) was reported before and after procedures. Pain assessment was lower for children undergoing Botulinum-toxin injections with clown-care (2.89± 1.36) compared to standard-care (3.85± 1.39; p = 0.036) even though pain anticipated prior to procedures was similar (~3).

findingsChildren who underwent the first procedure with clown-care reported lower pain even after they crossed-over to the following procedure which was standard (p = 0.048). Carryover effect was more prominent in injection-naïve children (p = 0.019) and during multiple procedures (p = 0.009). Prior pain experience correlated with pain in subsequent procedures only when first experience was standard-care (p = 0.001).

conclusionsClown-care alleviated pain sensation during Botulinum-toxin injections and initial clown-care experience reduced pain during subsequent injections even though clowns were not present.

trial registrationclinicaltrials.gov ID # NCT01377883.

Indexed as

AdolescentBotulinum ToxinsCerebral PalsyChildChild, PreschoolCross-Over StudiesFemaleHumansInfantInjections, IntramuscularIsraelLaughter TherapyMaleMuscle HypertoniaNeuromuscular AgentsPainBotulinum ToxinsNeuromuscular Agents

Identifiers

PMID28414728
PMCPMC5393564
OpenAlexW2605480593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.