ArticlePLoS computational biology2017
Dynamics of adaptive immunity against phage in bacterial populations.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- My host's enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages.Proceedings. Biological sciences · 2024Article
- Article
- Epidemiological and evolutionary consequences of different types of CRISPR-Cas systems.PLoS computational biology · 2022Article
- Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage ΦD5 results in fitness tradeoffs for the bacterium during infection.Scientific reports · 2022Article
- Single cell variability of CRISPR-Cas interference and adaptation.Molecular systems biology · 2022Article
- Ecological memory preserves phage resistance mechanisms in bacteria.Nature communications · 2021Article
- Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.Proceedings. Biological sciences · 2021Article
- Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback.iScience · 2021Article
- Application of Bacteriophages to LimitFrontiers in microbiology · 2021Review
- CRISPR recognizes as many phage types as possible without overwhelming the Cas machinery.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Why put up with immunity when there is resistance: an excursion into the population and evolutionary dynamics of restriction-modification and CRISPR-Cas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Cost and benefits of clustered regularly interspaced short palindromic repeats spacer acquisition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response.Cell host & microbe · 2019Article
- How adaptive immunity constrains the composition and fate of large bacterial populations.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Immune loss as a driver of coexistence during host-phage coevolution.The ISME journal · 2018Article
- Optimal number of spacers in CRISPR arrays.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CRISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adaptively defend against phages by acquiring short genomic sequences (spacers) that target specific sequences in the viral genome. We propose a population dynamical model where immunity can be both acquired and lost. The model predicts regimes where bacterial and phage populations can co-exist, others where the populations exhibit damped oscillations, and still others where one population is driven to extinction. Our model considers two key parameters: (1) ease of acquisition and (2) spacer effectiveness in conferring immunity. Analytical calculations and numerical simulations show that if spacers differ mainly in ease of acquisition, or if the probability of acquiring them is sufficiently high, bacteria develop a diverse population of spacers. On the other hand, if spacers differ mainly in their effectiveness, their final distribution will be highly peaked, akin to a "winner-take-all" scenario, leading to a specialized spacer distribution. Bacteria can interpolate between these limiting behaviors by actively tuning their overall acquisition probability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.