ArticleTissue engineering. Part A2017
Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms.
Article in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2019Pooled it
- TheMaterials today. Bio · 2026Review
- Multi-Scale Analysis of Regional Pathology in the Human Trapezium During Osteoarthritis Progression.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Biomechanical evaluation of a sheep tracheal scaffold.Cell and tissue banking · 2024Article
- Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model.JOR spine · 2023Article
- Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Article
- Six-Month Outcomes of Clinically Relevant Meniscal Injury in a Large-Animal Model.Orthopaedic journal of sports medicine · 2021Review
- The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.Acta biomaterialia · 2021Article
- An in vitro investigation to understand the synergistic role of MMPs-1 and 9 on articular cartilage biomechanical properties.Scientific reports · 2021Article
- Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis.Journal of clinical medicine · 2021Review
- Marked differences in local bone remodelling in response to different marrow stimulation techniques in a large animal.European cells & materials · 2021Article
- Nanofibrous hyaluronic acid scaffolds delivering TGF-β3 and SDF-1α for articular cartilage repair in a large animal model.Acta biomaterialia · 2021Article
- Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.European cells & materials · 2021Article
- Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Computational technology for nasal cartilage-related clinical research and application.International journal of oral science · 2020Review
- Effects of culture conditions on the mechanical and biological properties of engineered cartilage constructed with collagen hybrid scaffold and human mesenchymal stem cells.Journal of materials science. Materials in medicine · 2019Article
- Utilization of Finite Element Analysis for Articular Cartilage Tissue Engineering.Materials (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cartilage tissue engineering is emerging as a promising treatment for osteoarthritis, and the field has progressed toward utilizing large animal models for proof of concept and preclinical studies. Mechanical testing of the regenerative tissue is an essential outcome for functional evaluation. However, testing modalities and constitutive frameworks used to evaluate in vitro grown samples differ substantially from those used to evaluate in vivo derived samples. To address this, we developed finite element (FE) models (using FEBio) of unconfined compression and indentation testing, modalities commonly used for such samples. We determined the model sensitivity to tissue radius and subchondral bone modulus, as well as its ability to estimate material parameters using the built-in parameter optimization tool in FEBio. We then sequentially tested agarose gels of 4%, 6%, 8%, and 10% weight/weight using a custom indentation platform, followed by unconfined compression. Similarly, we evaluated the ability of the model to generate material parameters for living constructs by evaluating engineered cartilage. Juvenile bovine mesenchymal stem cells were seeded (2 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.