Evidence map›Paper›PMID 28414422›Full record

ArticleACS chemical neuroscience2017

Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT

Ying-Chu Chen, Rachel M Hartley, Noelle C Anastasio, Kathryn A Cunningham, Scott R Gilbertson

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in pharmacology · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ying-Chu ChenDepartment of Chemistry, University of Houston , Houston, Texas 77204, United States.
Rachel M Hartley
Noelle C Anastasio
Kathryn A CunninghamORCID 0000-0002-4257-1739
Scott R GilbertsonDepartment of Chemistry, University of Houston , Houston, Texas 77204, United States.ORCID 0000-0003-3665-5693
University of Houston · US

Funding

Translational Addiction Sciences CenterP50DA033935 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2013 to 2017
$6.7M
Translational Explorations in Substance Use DisordersT32DA007287 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 1994 to 2026
$4.7M
NIDA NIH HHS P50 DA033935NIDA NIH HHS T32 DA007287
6 · The paper itself

Abstract

The development of probe molecules that can be used to investigate G protein-coupled receptor (GPCR) pharmacology, trafficking, and relationship with other GPCRs is an important and growing area of research. Here, we report the synthesis of analogues of the known selective serotonin (5-HT) 5-HT

Indexed as

Structure-Activity RelationshipAnimalsAzepinesCalciumCell LineHumansIndolesSerotonin 5-HT2 Receptor AgonistsSignal Transduction1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleAzepinesCalciumIndolesSerotonin 5-HT2 Receptor Agonists5-HT2C receptor agonistSerotoninWAY163909 derivatives

Identifiers

PMID28414422
PMCPMC5664164
OpenAlexW2605871405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.