ArticleApplied optics2017
Sensitivity study of x-ray luminescence computed tomography.
Article in Applied optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging.IEEE access : practical innovations, open solutions · 2023Article
- Contrast agents for x-ray luminescence computed tomography.Applied optics · 2021Article
- Focused x-ray luminescence imaging system for small animals based on a rotary gantry.Journal of biomedical optics · 2021Article
- Review of in vivo optical molecular imaging and sensing from x-ray excitation.Journal of biomedical optics · 2021Review
- X-ray luminescence imaging for small animals.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- High-resolution x-ray luminescence computed tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Limited view cone-beam x-ray luminescence tomography based on depth compensation and group sparsity prior.Journal of biomedical optics · 2020Article
- Method for improving the spatial resolution of narrow x-ray beam-based x-ray luminescence computed tomography imaging.Journal of biomedical optics · 2019Article
- Focused x-ray luminescence computed tomography: experimental studies.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Background luminescence in x-ray luminescence computed tomography (XLCT) imaging.Applied optics · 2019Article
- Time domain X-ray luminescence computed tomography: numerical simulations.Biomedical optics express · 2019Article
- X-ray luminescence computed tomography using a focused x-ray beam.Journal of biomedical optics · 2017Article
- Anatomical image-guided fluorescence molecular tomography reconstruction using kernel method.Journal of biomedical optics · 2017Article
- Bright X-ray and up-conversion nanophosphors annealed using encapsulated sintering agents for bioimaging applications.Journal of materials chemistry. B · 2017Article
- Collimated superfine x-ray beam based x-ray luminescence computed tomography.Journal of X-ray science and technology · 2017Article
- Super-Fast Three-Dimensional Focused X-ray Luminescence Computed Tomography with a Gated Photon Counter.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
X-ray luminescence computed tomography (XLCT) is a hybrid molecular imaging modality that combines the merits of both x-ray imaging (high resolution) and optical imaging (high sensitivity). In this study, we have evaluated the sensitivity of XLCT with phantom experiments by scanning targets of different phosphor concentrations at different depths. We found that XLCT is capable of imaging targets of very low concentrations (27.6 μM or 0.01 mg/mL) at significant depths, such as 21 mm. Our results demonstrate that there is little variation in the reconstructed target size with a maximum target size error of 4.35% for different imaging depths for XLCT. We have, we believe for the first time, compared the sensitivity of XLCT with that of traditional computed tomography (CT) for phosphor targets. We found that XLCT's use of x-ray-induced photons provides much higher measurement sensitivity and contrast compared to CT, which provides image contrast solely based on x-ray attenuation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.