ArticleOncogene2017
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance.
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Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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0cells of the map it votes in
65citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
What it found
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Who cites it
65 citing papers in PubMed, 92 citations in OpenAlex.
- From matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis.Biogerontology · 2026Review
- Mitophagy interacts with mitochondrial dynamics and biogenesis, acting as a double-edged sword in digestive cancer.iScience · 2026Review
- Mitophagy in bladder cancer: a double-edged sword in tumor progression and therapy.Journal of translational medicine · 2026Review
- A PDGFRB-CD44-MIF crosstalk promotes cancer-associated cellular phenotypes in ATRT-TYR/MYC cell lines.Frontiers in oncology · 2026Article
- Interleukin-13 Promotes Accumulation of Esophageal Epithelial Mitochondria With Translational Implications for Eosinophilic Esophagitis.Cellular and molecular gastroenterology and hepatology · 2026Article
- CD44 signaling in skin wound healing and regeneration.Journal of translational medicine · 2025Review
- PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis.Journal for immunotherapy of cancer · 2025Article
- Mitophagy's impacts on cancer and neurodegenerative diseases: implications for future therapies.Journal of hematology & oncology · 2025Review
- Review
- Mechanism of SMYD2 promoting stemness maintenance of bladder cancer stem cells by regulating PYCR1 expression and PINK1/Parkin mitophagy pathway.International journal of oncology · 2025Article
- Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance.Journal of hematology & oncology · 2025Review
- Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence.Medical oncology (Northwood, London, England) · 2025Review
- Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors.Frontiers in immunology · 2025Review
- Osteosarcoma stem cells resist chemotherapy by maintaining mitochondrial dynamic stability via DRP1.International journal of molecular medicine · 2025Article
- Article
- Mitochondrial quality control in human health and disease.Military Medical Research · 2024Review
- Identification of HSPD1 as a novel invasive biomarker associated with mitophagy in pituitary adenomas.Translational oncology · 2024Article
- ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment.Carcinogenesis · 2024Article
- Cancer stem cell fate determination: mito-nuclear communication.Cell communication and signaling : CCS · 2023Review
- A p-Tyr42 RhoA Inhibitor Promotes the Regeneration of Human Corneal Endothelial Cells by Ameliorating Cellular Senescence.Antioxidants (Basel, Switzerland) · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
K A WhelanDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
P M ChandramouleeswaranDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
K TanakaDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
M NatsuizakaDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
M GuhaDepartment of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
S SrinivasanDepartment of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
D S DarlingDepartment of Oral Immunology and Infectious Diseases, and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, USA.
Y KitaDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
S NatsugoeDepartment of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
J D WinklerUniversity of Pennsylvania Abramson Cancer Center, Philadelphia, USA.
A J Klein-SzantoHistopathology Facility and Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, USA.
R K AmaravadiUniversity of Pennsylvania Abramson Cancer Center, Philadelphia, USA.
N G AvadhaniDepartment of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
A K RustgiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
H NakagawaDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
University of Pennsylvania · USKagoshima University · JPFox Chase Cancer Center · USUniversity of Louisville · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MTargeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MTransformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HIBSHOOSH, HANINA · 2003 to 2023
$31.7MUNIVERSITY OF PENNSYLVANIA TRAINING IN GASTROENTEROLOGYT32DK007066 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1986 to 2026
$11.7MThe functional role of mitophagy in esophageal cell biologyK01DK103953 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WHELAN, KELLY A · 2015 to 2019
$637kRole of Notch 1 signaling in esophageal carcinogenesisF32CA174146 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WHELAN, KELLY A · 2013 to 2015
$118kIntegrative mouse pathobiology: GI epithelial biology and geneticsK26RR032714 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI NAKAGAWA, HIROSHI · 2011 to 2011
$87kTotal Synthesis of Plocamium Polyhalogenated Monoterpenes, Analogues, and BiologiF31CA174176 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI VOGEL, CARL · 2013 to 2015
$83kNCI NIH HHS F31 CA174176NCI NIH HHS F32 CA174146NCI NIH HHS P01 CA098101NCI NIH HHS P01 CA114046NCI NIH HHS P30 CA006927NCRR NIH HHS K26 RR032714NIDDK NIH HHS K01 DK103953NIDDK NIH HHS P30 DK050306NIDDK NIH HHS T32 DK007066NIEHS NIH HHS P30 ES013508
Abstract
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient outcomes in various cancer types, the relationship between autophagy and cells with high CD44 expression remains incompletely understood. In transformed oesophageal keratinocytes, CD44
Indexed as
AutophagyCarcinoma, Squamous CellCell Line, TumorEpithelial-Mesenchymal TransitionEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaHumansHyaluronan ReceptorsKeratinocytesMitochondriaOxidation-ReductionOxidative StressRNA InterferenceTransforming Growth Factor betaUbiquitin-Protein LigasesCD44 protein, humanHyaluronan Receptorsparkin proteinTransforming Growth Factor betaUbiquitin-Protein Ligases
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.