Evidence map›Paper›PMID 28414261›Full record

ArticleAIDS patient care and STDs2017

"Support Your Client at the Space That They're in": HIV Pre-Exposure Prophylaxis (PrEP) Prescribers' Perspectives on PrEP-Related Risk Compensation.

Sarah K Calabrese, Manya Magnus, Kenneth H Mayer, Douglas S Krakower, Adam I Eldahan, Lauren A Gaston Hawkins, Kristen Underhill, Nathan B Hansen, Trace S Kershaw, Joseph R Betancourt and 1 more

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
  4. Parent-Adolescent Relationship Quality, Sexual Health Communication, and Willingness to Support Pre-Exposure Prophylaxis for HIV: A Qualitative Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah K Calabrese1 Department of Psychology, George Washington University , Washington, District of Columbia.
Manya Magnus4 Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University , Washington, District of Columbia.
Kenneth H Mayer5 The Fenway Institute , Fenway Health, Boston, Massachusetts.
Douglas S Krakower5 The Fenway Institute , Fenway Health, Boston, Massachusetts.
Adam I Eldahan2 Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, Connecticut.
Lauren A Gaston Hawkins2 Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, Connecticut.
Kristen Underhill3 Center for Interdisciplinary Research on AIDS, Yale University , New Haven, Connecticut.
Nathan B Hansen3 Center for Interdisciplinary Research on AIDS, Yale University , New Haven, Connecticut.
Trace S Kershaw2 Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, Connecticut.
Joseph R Betancourt12 Disparities Solutions Center, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts.
John F Dovidio2 Department of Chronic Disease Epidemiology, Yale School of Public Health , New Haven, Connecticut.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
The District of Columbia Developmental Center for AIDS Research (DC D-CFAR)P30AI087714 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GREENBERG, ALAN EDWARD · 2010 to 2014
$8.4M
Optimizing HIV Pre-Exposure Prophylaxis through Shared Decision MakingK23MH098795 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KRAKOWER, DOUGLAS SCOTT · 2012 to 2016
$873k
Intervention to Promote PrEP Awareness and Equitable Prescription among ProvidersK01MH103080 · NIMH · YALE UNIVERSITY · PI CALABRESE, SARAH K. · 2014 to 2017
$634k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P30 AI087714NIAID NIH HHS P30 AI117970NIMH NIH HHS K01 MH103080NIMH NIH HHS K23 MH098795
6 · The paper itself

Abstract

Despite the demonstrated effectiveness of HIV pre-exposure prophylaxis (PrEP) and evidence that most PrEP users do not engage in risk compensation (i.e., increased risk behavior due to a perceived decrease in HIV susceptibility), some healthcare providers report patient risk compensation to be a deterrent to prescribing PrEP. Overcoming this barrier is essential to supporting PrEP access and uptake among people at risk for HIV. To inform such efforts, this qualitative study explored PrEP-related risk compensation attitudes among providers with firsthand experience prescribing PrEP. US-based PrEP providers (n = 18), most of whom were HIV specialists, were recruited through direct outreach and referral from colleagues and other participants. Individual 90-min semistructured interviews were conducted by phone or in person from September 2014 through February 2015, transcribed, and thematically analyzed. Three attitudinal themes emerged: (1) providers' role is to support patients in making informed decisions, (2) risk behavior while taking PrEP does not fully offset PrEP's protective benefit (i.e., PrEP confers net protection, even with added behavioral risk), and (3) PrEP-related risk compensation is unduly stigmatized within and beyond the healthcare community. Participants were critical of other healthcare providers' negative judgment of patients and reluctance to prescribe PrEP due to anticipated risk compensation. Several providers also acknowledged an evolution in their thinking from initial ambivalence toward greater acceptance of PrEP and PrEP-related behavior change. PrEP providers' insights about risk compensation may help to address unsubstantiated concerns about PrEP-related risk compensation and challenge the acceptability of withholding PrEP on these grounds.

Indexed as

Attitude of Health PersonnelHealth Knowledge, Attitudes, PracticePerceptionAnti-HIV AgentsDrug PrescriptionsHealth Care SurveysHealth PersonnelHIV InfectionsHumansMalePre-Exposure ProphylaxisPrejudiceQualitative ResearchRisk-TakingStereotypingSurveys and QuestionnairesAnti-HIV Agentsbehavioral disinhibitioncondom attitudeshealthcare providersHIVpre-exposure prophylaxisrisk compensation

Identifiers

PMID28414261
PMCPMC5404273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.