Evidence map›Paper›PMID 28414197›Full record

ArticleActa pharmacologica Sinica2017

Engineering of a self-adjuvanted iTEP-delivered CTL vaccine.

Shuyun Dong, Tiefeng Xu, Peng Wang, Peng Zhao, Mingnan Chen

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Promotion of CTL epitope presentation by a nanoparticle with environment-responsive stability and phagolysosomal escape capacity.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cancer nanobiotechnolgy.Acta pharmacologica Sinica · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shuyun DongDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Tiefeng XuDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Peng WangDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Peng ZhaoDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Mingnan ChenDepartment of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
University of Utah · USHainan Medical University · CN

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Inhibition of metastasis-initiating cells by chimeric polypeptide nanoparticlesR00CA153929 · NCI · UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2012 to 2014
$721k
Enhancing cytotoxic T lymphocyte (CTL) responses by directly loading CTL epitope vaccines onto MHC Class I complexes on the dendritic cell surfaceR21EB024083 · NIBIB · UNIVERSITY OF UTAH · PI CHEN, MINGNAN · 2017 to 2018
$417k
NCI NIH HHS P30 CA042014NCI NIH HHS R00 CA153929NIBIB NIH HHS R21 EB024083
6 · The paper itself

Abstract

Cytotoxic T lymphocyte (CTL) epitope peptide-based vaccines are widely used in cancer and infectious disease therapy. We previously generated an immune-tolerant elastin-like polypeptides (iTEPs)-based carrier to deliver a peptide CTL vaccine and enhance the efficiency of the vaccine. To further optimize the vaccine carrier, we intended to potentiate its function by designing an iTEP-based carrier that was able to deliver adjuvant and a vaccine epitope as one molecule. Thus, we fused a 9-mer H

Indexed as

Adjuvants, ImmunologicProtein EngineeringAnimalsCell LineElastinEpitopes, T-LymphocyteFemaleImmune ToleranceMiceMice, Inbred C57BLPeptidesT-Lymphocytes, CytotoxicVaccines, SubunitAdjuvants, ImmunologicElastinEpitopes, T-LymphocytePeptidesVaccines, Subunit

Identifiers

PMID28414197
PMCPMC5520189
OpenAlexW2606904696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.