Evidence map›Paper›PMID 28414051›Full record

ReviewNeuropharmacology2017

Mechanisms contributing to cognitive deficits in cannabis users.

Romina Mizrahi, Jeremy J Watts, Kuei Y Tseng

Abstract readReview
In one paragraph

Review in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Cannabis increases susceptibility to false memory.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Trial
  2. Review
  3. Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  5. Article
  6. Observational
  7. Review
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Romina MizrahiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, ON, Canada; Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
Jeremy J WattsDepartment of Pharmacology & Toxicology, University of Toronto, ON, Canada; Research Imaging Center, CAMH, PET Centre, Toronto, ON, Canada.
Kuei Y TsengDepartment of Cellular & Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University, North Chicago, IL, USA. Electronic address: kuei-yuan.tseng@rosalindfranklin.edu.

Funding

Adolescent Maturation of the Prefrontal Cortex: Modulation by CannabinoidsR01MH105488 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TSENG, KUEI-YUAN · 2015 to 2019
$2.1M
NIMH NIH HHS R01 MH105488
6 · The paper itself

Abstract

Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use, in particular within the working memory and decision-making domains. Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function. This perspective review article provides an overview of current state of knowledge on possible neurobiological mechanisms accounting for the detrimental effects of chronic cannabis use on cognition and related changes in brain structure and functional connectivity. This article is part of the Special Issue entitled "A New Dawn in Cannabinoid Neurobiology".

Indexed as

AnimalsBrainCognition DisordersHumansMarijuana SmokingReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB1CannabinoidsCannabisCB1 receptorsCognitionConnectivityImagingPrefrontal cortexTHC

Identifiers

PMID28414051
PMCPMC5540783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.