ArticleAIMS neuroscience2016
Functions and Mechanisms of Sleep.
Article in AIMS neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 8 syntheses or guidelines pooled it, 317 citations in OpenAlex.
- A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models.Journal of sleep research · 2026Pooled it
- Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta-Analysis.Journal of sleep research · 2026Pooled it
- Brain connectivity changes associated with acute sleep deprivation: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Effect of acupuncture on cognitive impairment induced by sleep deprivation in animal models: a preclinical systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2023Pooled it
- Influencing factors of sleep disorders and sleep quality in healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis.Nursing open · 2023Pooled it
- Is exposure to chemical pollutants associated with sleep outcomes? A systematic review.Sleep medicine reviews · 2023Pooled it
- Physical activity and sleep: An updated umbrella review of the 2018 Physical Activity Guidelines Advisory Committee report.Sleep medicine reviews · 2021Pooled it
- Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin.The Journal of clinical investigation · 2026Trial
- The Effects of Excessive Arousing Video Gaming on vmHRV During Sleep in Habitual Gamers.Applied psychophysiology and biofeedback · 2026Trial
- Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.Neuroscience bulletin · 2026Article
- Tilia Tomentosa promotes sleep, preserving sleep structure.Npj biological timing and sleep · 2026Article
- Ketogenic diet for pediatric drug-resistant epilepsy: sleep, children's psychosocial functioning, and maternal mental health.Pediatric research · 2026Article
- Delaying Early Morning Training Time in Swimmers: Effects on Sleep, Recovery and Performance-A Randomized Controlled Trial.Sports medicine - open · 2026Article
- Sleep Quality in Spanish Adult Women: Associations with Sociodemographic Variables and Pre-Sleep Habits.Healthcare (Basel, Switzerland) · 2026Article
- Sleep Oscillations Across Cortical, Subcortical and Cerebellar Structures in Magnetoencephalography.The European journal of neuroscience · 2026Article
- Impact of sleep duration on bone mineral density and osteoporosis risk: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Review
- Prevalence of Poor Sleep Quality Among School Children in Chandigarh.Indian journal of pediatrics · 2026Article
- Delivery of HSP70 mRNA via exosomes ameliorates sleep deprivation-induced cognitive impairments in mice.Translational psychiatry · 2026Article
- Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.Molecular brain · 2026Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is a complex physiological process that is regulated globally, regionally, and locally by both cellular and molecular mechanisms. It occurs to some extent in all animals, although sleep expression in lower animals may be co-extensive with rest. Sleep regulation plays an intrinsic part in many behavioral and physiological functions. Currently, all researchers agree there is no single physiological role sleep serves. Nevertheless, it is quite evident that sleep is essential for many vital functions including development, energy conservation, brain waste clearance, modulation of immune responses, cognition, performance, vigilance, disease, and psychological state. This review details the physiological processes involved in sleep regulation and the possible functions that sleep may serve. This description of the brain circuitry, cell types, and molecules involved in sleep regulation is intended to further the reader's understanding of the functions of sleep.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.