ArticleeNeuro
Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta-analysis.Epilepsia · 2026Pooled it
- Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury.PNAS nexus · 2025Article
- Gestational iron deficiency affects the ratio between interneuron subtypes in the postnatal cerebral cortex in mice.Development (Cambridge, England) · 2023Article
- Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.Frontiers in neuroscience · 2023Review
- Brain-wide reconstruction of inhibitory circuits after traumatic brain injury.Nature communications · 2022Article
- Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Bad Timing for Epileptic Networks: Role of Temporal Dynamics in Seizures and Cognitive Deficits.Epilepsy currents · 2021Article
- Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Interneuron deficits in neurodevelopmental disorders: Implications for disease pathology and interneuron-based therapies.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020Review
- Transplanted interneurons improve memory precision after traumatic brain injury.Nature communications · 2019Article
- Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research.Frontiers in cellular neuroscience · 2018Review
- New Tools for Epilepsy Therapy.Frontiers in cellular neuroscience · 2018Review
- Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.Annals of neurology · 2017Article
- Neuronal Transplantation for Alzheimer's Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation.Cell transplantationReview
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy. While underlying mechanism(s) remains unclear to date, a simple explanation is that appropriate synaptic integration of MGE-derived interneurons elevates GABA-mediated inhibition and modifies the firing activity of excitatory neurons in the host brain. However, given the complexity of interneurons and potential for transplant-derived interneurons to integrate or alter the host network in unexpected ways, it remains unexplored whether synaptic connections formed by transplant-derived interneurons safely mirror those associated with endogenous interneurons. Here, we combined optogenetics, interneuron-specific Cre driver mouse lines, and electrophysiology to study synaptic integration of MGE progenitors. We demonstrated that MGE-derived interneurons, when transplanted into the hippocampus of neonatal mice, migrate in the host brain, differentiate to mature inhibitory interneurons, and form appropriate synaptic connections with native pyramidal neurons. Endogenous and transplant-derived MGE progenitors preferentially formed inhibitory synaptic connections onto pyramidal neurons but not endogenous interneurons. These findings demonstrate that transplanted MGE progenitors functionally integrate into the postnatal hippocampal network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.