ArticleNeuroImage. Clinical2017
Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- A Systematic Review of Non-invasive Brain Stimulation Applications to Memory in Healthy Aging.Frontiers in neurology · 2020Pooled it
- Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Elevated functional magnetic resonance imaging activity in cognitively normal participants predicts future dementia.Brain communications · 2026Article
- APOE ε4-related differences in brain structure, function, and connectivity at midlife: A scoping review.The journal of prevention of Alzheimer's disease · 2025Article
- Leading determinants of incident dementia among individuals with and without the apolipoprotein E ε4 genotype: a retrospective cohort study.BMC neurology · 2024Article
- Characteristics and Predictors of Alzheimer's Disease Resilience Phenotype.Journal of clinical medicine · 2023Article
- Effects of non-modifiable risk factors of Alzheimer's disease on intracortical myelin content.Alzheimer's research & therapy · 2022Article
- Tract-specific differences in white matter microstructure between young adultNeuroimage. Reports · 2022Article
- Magnetic Resonance Imaging Measurement of Entorhinal Cortex in the Diagnosis and Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease.Brain sciences · 2021Article
- Sex differences in brain aging among adults with family history of Alzheimer's disease and APOE4 genetic risk.NeuroImage. Clinical · 2021Article
- Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease.Neuroscience bulletin · 2020Article
- APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer's Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset.Journal of Alzheimer's disease : JAD · 2020Observational
- Multielement Episodic Encoding in Young and Older Adults.Journal of cognitive neuroscience · 2019Article
- Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing.Nature reviews. Neuroscience · 2018Article
- Functional brain network centrality is related to APOE genotype in cognitively normal elderly.Brain and behavior · 2018Article
- Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.Aging and disease · 2018Article
- Apolipoprotein E ε4 Specifically Modulates the Hippocampus Functional Connectivity Network in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Episodic memory impairment is a consistent, pronounced deficit in pre-clinical stages of late-onset Alzheimer's disease (AD). Individuals with risk factors for AD exhibit altered brain function several decades prior to the onset of AD-related symptoms. In the current event-related fMRI study of spatial context memory we tested the hypothesis that middle-aged adults (MA; 40-58 yrs) with a family history of late onset AD (MA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.