SynthesisBrain and behavior2017
Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation meta-analysis of fMRI studies.
Synthesis in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 10 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Reporting practices and sourcing of food images in fMRI research: implications for reproducibility.Frontiers in human neuroscience · 2026Pooled it
- Brain responses to watching food commercials compared with nonfood commercials: a meta-analysis on neuroimaging studies.Public health nutrition · 2021Pooled it
- Neural Correlates of Anti-appetite Medications: An fMRI Meta-analysis.Current neuropharmacology · 2021Pooled it
- Pooled it
- Hunger and BMI modulate neural responses to sweet stimuli: fMRI meta-analysis.International journal of obesity (2005) · 2020Pooled it
- Empirical assessment of changing sample-characteristics in task-fMRI over two decades: An example from gustatory and food studies.Human brain mapping · 2020Pooled it
- A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans.The Journal of nutrition · 2020Pooled it
- Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- Curcumin: Total-Scale Analysis of the Scientific Literature.Molecules (Basel, Switzerland) · 2019Pooled it
- Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation meta-analysis of fMRI studies.Brain and behavior · 2017Pooled it
- Savoring Satiety: An Exploratory Analysis of the Neural Correlates of Sensory-Specific Satiety.Nutrients · 2025Article
- A common neural code for representing imagined and inferred tastes.Progress in neurobiology · 2023Article
- Functional Neuroplasticity of Adults with Partial or Complete Denture Rehabilitation with or without Implants: Evidence from fMRI Studies.Nutrients · 2023Review
- Future Directions for Chemosensory Connectomes: Best Practices and Specific Challenges.Frontiers in systems neuroscience · 2022Article
- Interconnected sub-networks of the macaque monkey gustatory connectome.Frontiers in neuroscience · 2022Article
- The processing of visual food cues during bitter aftertaste perception in females with high vs. low disgust propensity: an fMRI study.Brain imaging and behavior · 2021Article
- Effective Connectivity in the Human Brain for Sour Taste, Retronasal Smell, and Combined Flavour.Foods (Basel, Switzerland) · 2021Article
- Viewing images of foods evokes taste quality-specific activity in gustatory insular cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Association of Disinhibited Eating and Trait of Impulsivity With Insula and Amygdala Responses to Palatable Liquid Consumption.Frontiers in systems neuroscience · 2021Article
- Network organization during probabilistic learning via taste outcomes.Physiology & behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNumerous task-based functional magnetic resonance imaging (fMRI) studies have reported the locations of basic taste representations in the human brain, but they usually employed a limited number of subjects (<20) with different methodologies and stimuli. Moreover, the reported brain regions were sometimes inconsistent. Thus, we aimed at performing a meta-analysis of the published data to identify locations consistently activated across studies, and performed a connectivity analysis to reveal how these taste processing regions connect with other brain regions. MATERIALS AND
methodsA meta-analysis was performed based on 34 experiments, with 238 total participants in 16 studies, to establish the activation likelihood estimation (ALE) of taste-mediated regional activation. Meta-analytic connectivity modeling (MACM) and data stored in BrainMap database were employed to reveal the functional connectivity of the regions identified by ALE with other brain regions, across all types of experiments that caused activation among healthy subjects.
resultsALE identified nine activated clusters in bilateral anteroventral and middle dorsal insulae, bilateral thalamus and caudate, bilateral pre-/postcentral gyrus, and right hippocampus. The concurrence between studies was moderate, with at best 38% of experiments contributed to the significant clusters activated by taste stimulation. Sweet taste was the predominant contributing taste. MACM revealed that at least 50% of the nine clusters coactivated with the middle cingulate cortex, medial frontal gyrus, inferior parietal lobule, and putamen.
conclusionResults suggested that fMRI studies have reported reproducible patterns of activations across studies. The basic taste stimulations resulted in activations in a mostly bilateral network. Moreover, they were connected with cognitive and emotional relevant brain regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.