ArticleBrain and behavior2017
Prevalence of potential sports-associated risk factors in Swiss amyotrophic lateral sclerosis patients.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Greek Registry for Amyotrophic Lateral Sclerosis (ALS-GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece.European journal of neurology · 2025Observational
- Croplands proximity is associated with amyotrophic lateral sclerosis incidence and age at onset.European journal of neurology · 2025Article
- Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.Brain communications · 2025Review
- Sports and trauma as risk factors for Motor Neurone Disease: New Zealand case-control study.Acta neurologica Scandinavica · 2022Article
- Physical activities and risk of neurodegenerative diseases: A two-sample Mendelian randomization study.Frontiers in aging neuroscience · 2022Article
- Article
- Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study.International journal of environmental research and public health · 2020Article
- Neurocognitive performance and mental health of retired female football players compared to non-contact sport athletes.BMJ open sport & exercise medicine · 2020Article
- Can Therapeutic Exercise Slow Down Progressive Functional Decline in Patients With Amyotrophic Lateral Sclerosis? A Meta-Analysis.Frontiers in neurology · 2020Review
- Defining pre-symptomatic amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Review
- Recumbent stepping aerobic exercise in amyotrophic lateral sclerosis: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Influence of Environment and Lifestyle on Incidence and Progress of Amyotrophic Lateral Sclerosis in A German ALS Population.Aging and disease · 2019Article
- Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.Human molecular genetics · 2018Article
- Effects of Ovariectomy in an hSOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Prevalence of potential sports-associated risk factors in Swiss amyotrophic lateral sclerosis patients.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAmyotrophic lateral sclerosis (ALS) has been reported to occur with increased incidence amongst physically active people. The role of extrinsic risk factors as physical activity, head trauma and drug/pesticide-exposure in the pathophysiology of ALS and especially in the context of practising sports remains controversial. MATERIALS AND
methodsWe retrospectively studied exposure to extrinsic factors in 92 ALS patients in the presymptomatic stage. Metabolic equivalents (METs) were calculated and the association of physical activity, drug intake, head trauma and participation in specific sports (football [soccer], ice hockey) with age at symptom-onset was evaluated.
resultsNinety-five percent of patients considered themselves physically active before symptom-onset. Total MET-values varied broadly and there was no correlation between vigorous physical activity and age at symptom-onset. Mild traumatic brain injury (prevalence = 16.7%) was the most frequent diagnosis after head/neck injury. A history of ≥1 head/neck injuries was associated with a younger age at symptom-onset (61.8 ± 11.0 vs. 54.1 ± 13.0,
conclusionsHistory of head injuries was the only extrinsic risk factor associated with accelerated neurodegeneration in ALS. There was no evidence for extrinsic factors predisposing former football and ice hockey players to ALS. Our data therefore support the hypothesis that not increased physical activity per se, but other unknown environmental factors and/or genetic profile or lifestyle-promoting physical fitness increases ALS susceptibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.