Evidence map›Paper›PMID 28413459›Full record

ArticleExperimental and therapeutic medicine2017

Expression levels of TGF-β1 and CTGF are associated with the severity of Duchenne muscular dystrophy.

Yanmin Song, Shuai Yao, Yunhai Liu, Lili Long, Huan Yang, Qiuxiang Li, Jinghui Liang, Xinxin Li, Yuling Lu, Haoran Zhu and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yanmin SongDepartment of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Shuai YaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Yunhai LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Lili LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Huan YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Qiuxiang LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Jinghui LiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Xinxin LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Yuling LuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Haoran ZhuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Ning ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Xiangya Hospital Central South University · CNCentral South University · CNWuxi Taihu Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to analyze the association of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) expression levels in skeletal muscle with the clinical manifestation of Duchenne muscular dystrophy (DMD). A total of 18 cases of DMD, which were confirmed by routine pathological diagnosis were recruited into the present study, along with 8 subjects who suffered from acute trauma but did not present any neuromuscular diseases and were enrolled as the healthy controls. Immunohistochemical staining was used to detect the expression levels of CTGF and TGF-β1 in muscle biopsy specimens. Furthermore, Spearman rank correlation analysis was conducted among the expression levels of CTGF and TGF-β1, age, clinical severity and pathological severity in DMD patients. The immunohistochemical staining results revealed that the expression levels of CTGF and TGF-β1 were significantly increased in the DMD group compared with those in the control group (P<0.05). These levels were not found to be significantly correlated with the onset age (P>0.05), but there was a significant correlation with the degree of pathology and clinical severity (P<0.05). In conclusion, an upregulated expression of CTGF and TGF-β1 was revealed in the skeletal muscle of DMD patients, which were in positive correlation with the degree of pathology and clinical severity. These two factors may be involved in the pathophysiology of fibrosis in DMD.

Indexed as

connective tissue growth factorDuchenne muscular dystrophydystrophinfibrosisimmunohistochemical stainingtransforming growth factor-β1

Identifiers

PMID28413459
PMCPMC5377242
OpenAlexW2587014439

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.