Evidence map›Paper›PMID 28413380›Full record

ArticleCurrent urology2017

Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in Cancer Bladder: Schistosomal and Non-Schistosomal.

Afkar A Badawy, Ali El-Hindawi, Olfat Hammam, Mona Moussa, Noha S Helal, Amira Kamel

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Afkar A BadawyDepartment of Pathology, Theodor Bilharz Research Institute, Giza, Egypt, Cairo University, Giza, Egypt.
Ali El-HindawiDepartment of Pathology, Faculty of Medicine, Cairo University, Giza, Egypt.
Olfat HammamDepartment of Pathology, Theodor Bilharz Research Institute, Giza, Egypt, Cairo University, Giza, Egypt.
Mona MoussaDepartment of Pathology, Theodor Bilharz Research Institute, Giza, Egypt, Cairo University, Giza, Egypt.
Noha S HelalDepartment of Pathology, Theodor Bilharz Research Institute, Giza, Egypt, Cairo University, Giza, Egypt.
Amira KamelDepartment of Pathology, Theodor Bilharz Research Institute, Giza, Egypt, Cairo University, Giza, Egypt.
Theodor Bilharz Research Institute · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOverexpression of epidermal growth factor receptor (EGFR) has been described in several solid tumors including bladder cancer. Transforming growth factor alpha (TGFα) is frequently deregulated in neoplastic cells and plays a role in the development of bladder cancer. TGFα-EGFR ligand-receptor combination constitutes an important event in multistep tumorigenesis.

methodsThis study was done on 30 bladder biopsies from patients with urothelial carcinoma, 15 with squamous cell carcinoma, 10 with cystitis and 5 normal control bladder specimens. All were immuohistochemically stained with EGFR and TGFα antibodies.

resultsEGFR and TGFα were over-expressed in higher grades and late stages of bladder cancer. Moreover, they show higher expression in squamous cell carcinoma compared to urothelial carcinoma and in schistosomal associated lesions than in non-schistosomal associated lesions.

conclusionEGFR and TGFα could be used as prognostic predictors in early stage and grade of bladder cancer cases, especially those with schistosomal association. In addition they can help in selecting patients who can get benefit from anti-EGFR molecular targeted therapy.

Indexed as

Bladder cancerEpidermal growth factor receptorImmunohistochemistrySchistosomiasisTransforming growth factor-α

Identifiers

PMID28413380
PMCPMC5385452
OpenAlexW2580781011

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.