ReviewJournal of anaesthesiology, clinical pharmacology
Vasopressors: Do they have any role in hemorrhagic shock?
Review in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04497155 (The Association of Norepinephrine Use in Pre-hospital Transport and Early Mortality in Hemorrhagic Shock), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association of Norepinephrine Use in Pre-hospital Transport and Early Mortality in Hemorrhagic Shock
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Blood Product Utilization in Thromboelastography-Aided Transfusion in Gastrointestinal Bleeding: A Single-Center Experience.Gastroenterology research · 2025Article
- Shock epidemiology and outcomes among internal medicine patients.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- Effect of Centhaquine on the Coagulation Cascade in Normal State and Uncontrolled Hemorrhage: A Multiphase Study Combining Ex Vivo and In Vivo Experiments in Different Species.International journal of molecular sciences · 2024Article
- Relative sparsity for medical decision problems.Statistics in medicine · 2023Article
- Effects of Vasopressin Receptor Agonists during the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies.Journal of personalized medicine · 2023Article
- Effect of C-Clamp Application on Hemodynamic Instability in Polytrauma Victims with Pelvic Fracture.Medicina (Kaunas, Lithuania) · 2022Article
- Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock.Intensive care medicine experimental · 2022Article
- Isolated liver trauma: A clinical perspective in a non-emergency center for liver surgery.Experimental and therapeutic medicine · 2022Article
- Low-dose norepinephrine in combination with hypotensive resuscitation may prolong the golden window for uncontrolled hemorrhagic shock in rats.Frontiers in physiology · 2022Article
- Severe traumatic brain injury and hypotension is a frequent and lethal combination in multiple trauma patients in mountain areas - an analysis of the prospective international Alpine Trauma Registry.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- N-Methyl-D-aspartate Glutamate Receptor Modulates Cardiovascular and Neuroendocrine Responses Evoked by Hemorrhagic Shock in Rats.BioMed research international · 2021Article
- A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs.Frontiers in pharmacology · 2021Article
- Measurement of mean systemic filling pressure after severe hemorrhagic shock in swine anesthetized with propofol-based total intravenous anesthesia: implications for vasopressor-free resuscitation.Acute and critical care · 2020Article
- Management of Pelvic Ring Injury Patients With Hemodynamic Instability.Frontiers in surgery · 2020Review
- Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest.Critical care (London, England) · 2019Article
- Effectiveness of arginine vasopressin for the management of refractory hemorrhagic shock in a patient with autonomic dysreflexia caused by spinal cord injury.JA clinical reports · 2018Article
- Effects of the Kv7 voltage-activated potassium channel inhibitor linopirdine in rat models of haemorrhagic shock.Clinical and experimental pharmacology & physiology · 2018Article
- [Hypovolemic and hemorrhagic shock].Der Anaesthesist · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The priority in the management of patients with traumatic hemorrhagic shock is to control the bleeding with simultaneous volume resuscitation to maintain adequate tissue perfusion. Fluid replacement remains the mainstay of initial resuscitation in hemorrhagic shock. Traditionally, vasopressors are contraindicated in the early management of hemorrhagic shock due to their deleterious consequences, although vasopressors may have a role in resuscitation when vasoplegic shock ensues and blood pressure cannot be maintained by fluids alone. Use of vasopressors is not recommended according to the Advanced Trauma Life SupportR management principles. The role of vasopressors remains controversial with no clear guidelines on the timing, type, and dose of these drugs in hemorrhagic shock. Among vasopressors, norepinephrine and vasopressin have been used in the majority of the trials, although not many studies compare the effect of these two on long-term survival in trauma patients. This article reviews the pathophysiology of hemorrhagic shock, adverse effects of fluid resuscitation, and the various experimental and clinical studies on the use of vasopressors in the early phase of resuscitation in hemorrhagic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.