ArticlePsychopharmacology2017
Drug cue reactivity involves hierarchical instrumental learning: evidence from a biconditional Pavlovian to instrumental transfer task.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Differences in Magnitude of Cue Reactivity Across Durations of Smoking History: A Meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Pooled it
- Appetitive Pavlovian-to-Instrumental Transfer in Participants with Normal-Weight and Obesity.Nutrients · 2019Trial
- The BioSUD Biobank as a genomic resource for substance use disorders in Italy.Scientific reports · 2025Article
- Transfer from goal-directed behavior to stimulus-response habits and its modulation by acute stress in individuals with risky gaming behavior.Scientific reports · 2024Article
- Enhanced Pavlovian-to-instrumental transfer in internet gaming disorder.Journal of behavioral addictions · 2023Article
- Effects of a brief mindfulness meditation practice on Pavlovian-to-instrumental transfer in alcohol use disorder - a pilot study.Frontiers in psychiatry · 2023Article
- Effective Connectivity during an Avoidance-Based Pavlovian-to-Instrumental Transfer Task.Brain sciences · 2021Article
- Human appetitive Pavlovian-to-instrumental transfer: a goal-directed account.Psychological research · 2021Review
- A Novel Cognition-Guided Neurofeedback BCI Dataset on Nicotine Addiction.Frontiers in neuroscience · 2021Article
- State anxiety and alcohol choice: Evidence from experimental and online observational studies.Journal of psychopharmacology (Oxford, England) · 2020Observational
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders.Psychopharmacology · 2020Article
- Subliminal determinants of cue-guided choice.Scientific reports · 2020Article
- Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Intact corticostriatal control of goal-directed action in Alcohol Use Disorder: a Pavlovian-to-instrumental transfer and outcome-devaluation study.Scientific reports · 2020Article
- An Adaptation of Pavlovian-to-Instrumental Transfer (PIT) Methodology to Examine the Energizing Effects of Reward-Predicting Cues on Behavior in Young Adults.Frontiers in psychology · 2020Article
- Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers: Behavioral, Neural and Polygenic Correlates.Journal of clinical medicine · 2019Article
- Individual differences in working memory capacity and cue-guided behavior in humans.Scientific reports · 2019Observational
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleDrug cue reactivity plays a crucial role in addiction, yet the underlying mechanisms are poorly understood. According to the binary associative account, drug stimuli retrieve an expectation of the drug outcome, which, in turn, elicits the associated drug-seeking response (S-O-R). By contrast, according to the hierarchical account, drug stimuli retrieve an expectation that the contingency between the drug-seeking response and the drug outcome is currently more effective, promoting performance of the drug-seeking response (S:R-O).
methodsThe current study discriminated between these two accounts using a biconditional Pavlovian-to-instrumental transfer (PIT) task with 128 alcohol drinkers. A biconditional discrimination was first trained in which two responses produced alcohol and food outcomes, respectively, and these response-outcome contingencies were reversed across two discriminative stimuli (SDs). In the PIT test, alcohol and food cues were compounded with the two SDs to examine their impact on percent alcohol choice in extinction.
resultsIt was found that alcohol and food cues selectively primed choice of the response that earned that outcome in each SD (p < .001), and this effect was associated with participants' belief that cues signalled greater effectiveness of that response (p < .0001).
conclusionsThe alcohol stimulus could not have selectively primed the alcohol-seeking response through binary S-O-R associations because the drug outcome was equally associated with both responses. Rather, the alcohol stimulus must have retrieved an expectation that the response-alcohol contingency available in the current context was more likely to be effective (S:R-O), which primed performance of the alcohol-seeking response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.