Evidence map›Paper›PMID 28412762›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2017

Sleep Deprivation and Late Bedtime Impair Sperm Health Through Increasing Antisperm Antibody Production: A Prospective Study of 981 Healthy Men.

Mei-Mei Liu, Li Liu, Liang Chen, Xiao-Jing Yin, Hui Liu, Yan-Hua Zhang, Pei-Ling Li, Shan Wang, Xiao-Xiao Li, Cai-Hong Yu

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mei-Mei LiuDepartment of Obstetrics and Gynecology, Second Affiliated Hospital Harbin, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Li LiuDepartment of Obstetrics and Gynecology, Harbin Red Cross Central Hospital, Harbin, Heilongjiang, China (mainland).
Liang ChenDepartment of Obstetrics and Gynecology, Second Affiliated Hospital Harbin, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Xiao-Jing YinDepartment of Obstetrics and Gynecology, Chaoyang Central Hospital, Chaoyang, Heilongjiang, China (mainland).
Hui LiuDepartment of Obstetrics and Gynecology, Second Affiliated Hospital Harbin, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Yan-Hua ZhangDepartment of Obstetrics and Gynecology, Second Affiliated Hospital Harbin, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Pei-Ling LiDepartment of Obstetrics and Gynecology, Second Affiliated Hospital Harbin, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Shan WangDepartment of Obstetrics and Gynecology, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Xiao-Xiao LiDepartment of Obstetrics and Gynecology, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Cai-Hong YuDepartment of Obstetrics and Gynecology, Harbin Medical University, Harbin, Heilongjiang, China (mainland).
Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CNBeijing Chaoyang Emergency Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The aim of this study was to investigate the effects of sleep duration and bedtime on sperm health, and the possible mechanism involved. MATERIAL AND METHODS We randomly divided 981 healthy Chinese men into groups according to research-set bedtimes (A=8-10 PM, B=after 10 PM, and C=after midnight) and sleep durations: group 1=<6.0 h (short), group 2=7.0-8.0 h (average), and group 3=>9.0 h (long). Sperm morphology, count, survival, and motility were examined according to sleep patterns. Antisperm antibody (ASA) production in semen was determined. RESULTS Sperm counts and their survival rates were lower in the short sleepers as compared to others within each group (all P<0.01). The lower counts and survival rates were observed in different bedtimes, with significant differences found between measurements of C1 vs. A1 and C2 vs. A2 or B2 (all P<0.05 or 0.01). Semen motility was lower in the short sleepers as compared to the average and long sleepers (all P<0.01). There were differences in the bedtime-related results between measurements of C1 vs. A1 or B1 (P<0.05 or 0.01). Additionally, the population proportion for the ASA-positive participates and incidence of the ASA-expressed population obviously increased in the short sleepers as compared to others within each group (all P<0.05). CONCLUSIONS Short and long sleep durations and late bedtime were associated with impaired sperm health in the study cohort, partly through increasing ASA production in the semen.

Indexed as

AdultAgedAntibody FormationCase-Control StudiesChinaHumansMaleMiddle AgedProspective StudiesSemenSleepSleep DeprivationSpermatozoaSperm Motility

Identifiers

PMID28412762
PMCPMC5402839
OpenAlexW2606817110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.