ArticleOncotarget2017
Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population.BMC medical genomics · 2021Article
- An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults:Aging · 2021Article
- A population-based prospective study on rest-activity rhythm and mild cognitive impairment among Hong Kong healthy community-dwelling older adults.Neurobiology of sleep and circadian rhythms · 2021Article
- CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption.Scientific reports · 2020Article
- Precision Psychiatry Applications with Pharmacogenomics: Artificial Intelligence and Machine Learning Approaches.International journal of molecular sciences · 2020Review
- Association and Interaction Effects of Interleukin-12 Related Genes and Physical Activity on Cognitive Aging in Old Adults in the Taiwanese Population.Frontiers in neurology · 2019Article
- Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection.Frontiers in neurology · 2018Article
- Critical Issues inFrontiers in molecular neuroscience · 2018Review
- Detection of susceptibility loci onOncotarget · 2017Article
- Transforming growth factor-β signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population.Scientific reports · 2017Article
- Article
- Genetic Biomarkers on Age-Related Cognitive Decline.Frontiers in psychiatry · 2017Review
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Authors and funding
6 authors.
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Abstract
Previous animal studies have indicated associations between circadian clock genes and cognitive impairment . In this study, we assessed whether 11 circadian clockgenes are associated with cognitive aging independently and/or through complex interactions in an old Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing cognitive aging. A total of 634 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examinations (MMSE) were administered to all subjects, and MMSE scores were used to evaluate cognitive function. Our data showed associations between cognitive aging and single nucleotide polymorphisms (SNPs) in 4 key circadian clock genes, CLOCK rs3749473 (p = 0.0017), NPAS2 rs17655330 (p = 0.0013), RORA rs13329238 (p = 0.0009), and RORB rs10781247 (p = 7.9 x 10-5). We also found that interactions between CLOCK rs3749473, NPAS2 rs17655330, RORA rs13329238, and RORB rs10781247 affected cognitive aging (p = 0.007). Finally, we investigated the influence of interactions between CLOCK rs3749473, RORA rs13329238, and RORB rs10781247 with environmental factors such as alcohol consumption, smoking status, physical activity, and social support on cognitive aging (p = 0.002 ~ 0.01). Our study indicates that circadian clock genes such as the CLOCK, NPAS2, RORA, and RORB genes may contribute to the risk of cognitive aging independently as well as through gene-gene and gene-environment interactions.
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