Evidence map›Paper›PMID 28412589›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2017

Emergency admission and survival from aggressive non-Hodgkin lymphoma: A report from the UK's population-based Haematological Malignancy Research Network.

Eleanor Kane, Debra Howell, Alexandra Smith, Simon Crouch, Cathy Burton, Eve Roman, Russell Patmore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. Disease-related factors affecting timely lymphoma diagnosis: a qualitative study exploring patient experiences.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eleanor KaneEpidemiology & Cancer Statistics Group, Department of Health Sciences, University of York, York, YO10 5DD, UK.
Debra HowellEpidemiology & Cancer Statistics Group, Department of Health Sciences, University of York, York, YO10 5DD, UK.
Alexandra SmithEpidemiology & Cancer Statistics Group, Department of Health Sciences, University of York, York, YO10 5DD, UK.
Simon CrouchEpidemiology & Cancer Statistics Group, Department of Health Sciences, University of York, York, YO10 5DD, UK.
Cathy BurtonHaematological Malignancy Diagnostic Service, Bexley Wing, St James's University Hospital, Leeds, LS9 7TF, UK.
Eve RomanEpidemiology & Cancer Statistics Group, Department of Health Sciences, University of York, York, YO10 5DD, UK. Electronic address: eve.roman@york.ac.uk.
Russell PatmoreQueen's Centre for Oncology and Haematology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-Hodgkin lymphoma (NHL) is often diagnosed after emergency presentation, a route associated with poor survival and an indicator of diagnostic delay. Accounting for around half of all NHLs, diffuse large B-cell lymphoma (DLBCL) is of particular interest since although it is potentially curable with standardised chemotherapy it can be challenging to identify at an early stage in the primary care setting. PATIENTS AND

methodsSet within a socio-demographically representative United Kingdom population of around 4 million people, data are from an established patient cohort. This report includes all patients (≥18 years) diagnosed with DLBCL 2004-2011 (n = 1660). Emergency admissions were identified via linkage to Hospital Episode Statistics using standard methods, and survival was examined using proportional hazards regression.

resultsTwo out of every five patients were diagnosed following an emergency admission, and this was associated with advanced disease and poor survival (p < 0.001). Among the 80% of patients treated with curative chemotherapy, survival discrepancies emerged at the point of diagnosis; the adjusted hazard ratio (emergency versus non-emergency) at one month being 4.0 (95% confidence interval 1.9-8.2). No lasting impact was evident in patients who survived for 12 months or more.

conclusionEmergency presentation impacts negatively on DLBCL survival; patients presenting via this route have significantly poorer outcomes than patients with similar clinical characteristics who present via other routes.

Indexed as

AdolescentAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolDelayed DiagnosisEmergenciesEmergency Service, HospitalEmergency TreatmentFemaleHumansInfantInfant, NewbornLymphoma, Non-HodgkinMaleDiffuse-large b-cell lymphomaEmergency presentationNon-Hodgkin lymphomaSurvival

Identifiers

PMID28412589
PMCPMC5446261

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.