ReviewMolecular and cellular endocrinology2017
Nutrition modulation of human aging: The calorie restriction paradigm.
Review in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06271200 (Effects of Intensive Lifestyle Interventions), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Intensive Lifestyle Interventions (ILI) on Weight Loss and Cardiometabolic Risks in Obese Adults With Metabolic Syndrome: A Randomized Clinical Trial
Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification.Aging cell · 2023Trial
- Nutritional quality of calorie restricted diets in the CALERIE™ 1 trial.Experimental gerontology · 2022Trial
- Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review.Clinical interventions in aging · 2026Review
- Sphingolipid and methionine metabolism in aging.Journal of cell science · 2025Review
- Calorie restriction mimetics against aging and inflammation.Biogerontology · 2025Review
- Increasing the health span: unique role for exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Review
- Calorie Restriction Decreases Competitive Fitness inMicroorganisms · 2024Article
- How calorie restriction slows aging: an epigenetic perspective.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male rats.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2024Article
- Inflammaging and Osteoarthritis.Clinical reviews in allergy & immunology · 2023Review
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
- Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.Experimental gerontology · 2022Article
- Role of Diet in Stem and Cancer Stem Cells.International journal of molecular sciences · 2022Review
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Pharmacological Approaches to Decelerate Aging: A Promising Path.Oxidative medicine and cellular longevity · 2022Review
- The promise of neuroprotection by dietary restriction in glaucoma.Neural regeneration research · 2022Article
- Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study.The journal of nutrition, health & aging · 2022Article
- Healthy Aging-Nutrition Matters: Start Early and Screen Often.Advances in nutrition (Bethesda, Md.) · 2021Review
- Value-based eating habits; exploring religio-cultural nutritional behavior norms.Journal of diabetes and metabolic disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is calorie restriction (CR), or the restriction of energy intake while maintaining intake of essential nutrients. The burgeoning evidence for this approach in humans is reviewed and the major study to date to address this question, CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy), is described. CALERIE findings indicate the feasibility of CR in non-obese humans, confirm observations in NHP, and are consistent with improvements in disease risk reduction and potential anti-aging effects. Finally, the mechanisms of CR in humans are reviewed which sums up the fact that evolutionarily conserved mechanisms mediate the anti-aging effects of CR. Overall, the prospect for further research in both NHP and humans is highly encouraging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.