ArticleBone2017
Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice.
Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects.Bioactive materials · 2023Article
- Single-cell RNA sequencing in orthopedic research.Bone research · 2023Review
- Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation.Frontiers in physiology · 2023Article
- Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PARScientific reports · 2022Article
- Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues.Journal of cellular physiology · 2022Article
- Subchondral bone microenvironment in osteoarthritis and pain.Bone research · 2021Review
- Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing.Frontiers in endocrinology · 2021Article
- Articular cartilage regeneration by activated skeletal stem cells.Nature medicine · 2020Article
- AnFrontiers in bioengineering and biotechnology · 2020Article
- Bioinformatics Analysis of the Molecular Mechanism of Late-Stage Heterotopic Ossification.BioMed research international · 2020Article
- Effects of Bone Morphogenetic Protein-2 on Neovascularization During Large Bone Defect Regeneration.Tissue engineering. Part A · 2019Article
- VEGFA From Early Osteoblast Lineage Cells (Osterix+) Is Required in Mice for Fracture Healing.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Chondrocytes Promote Vascularization in Fracture Healing Through a FOXO1-Dependent Mechanism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Ischaemia, healing and outcomes in proximal humeral fractures.EFORT open reviews · 2018Article
- Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Endochondral ossification is the process where cartilage forms prior to ossification and in which new bone forms during both fracture healing and ectopic bone formation. Transitioning to ossification is a highly coordinated process between hypertrophic chondrocytes, vascular endothelial cells, osteoblasts and osteoclasts. A critical biological process that is central to the interactions of these various cell types is angiogenesis. Although it is well established that angiogenesis is crucial for fracture repair, less is known pertaining to the role of angiogenesis in ectopic bone formation. Furthermore, fracture repair models are complicated by extensive trauma, subsequent inflammatory responses and concurrent repair processes in multiple tissues. In order to more definitively characterize the relationship between angiogenesis and postnatal endochondral ossification, a model of ectopic bone formation was used. Human demineralized bone matrix (DBM) was implanted in immune-deficient mice (rag null (B6.129S7-Rag1
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.