Trial reportClinical biochemistry2017
Effects of preanalytical factors on hemoglobin measurement: A comparison of two HemoCue® point-of-care analyzers.
Trial report in Clinical biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Use of point-of-care haemoglobin tests to diagnose childhood anaemia in low- and middle-income countries: A systematic review.Tropical medicine & international health : TM & IH · 2024Pooled it
- Associations between type of blood collection, analytical approach, mean haemoglobin and anaemia prevalence in population-based surveys: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Trial
- Validation of HemoCue method and development of a revised hemoglobin cut-off to detect anemia in children aged 6-24-months.PloS one · 2026Article
- Anemia crisis among children in Peru: a scoping review.Revista panamericana de salud publica = Pan American journal of public health · 2026Review
- Method Comparison and Investigation of Interference Variables of a Hand-Held Hemoglobinometer(HemoCue Hb 201Veterinary clinical pathology · 2025Article
- Evaluation of the Performance of Portable Hemoglobinometers at Measuring Hemoglobin and Detecting Anemia in a Periurban Pediatric Population in Lima, Peru.The American journal of tropical medicine and hygiene · 2025Article
- Emerging Evidence and Critical Issues with the Use of Single-Drop Capillary Blood for the Measurement of Hemoglobin Concentration in Population-Level Anemia Surveys.Advances in nutrition (Bethesda, Md.) · 2024Article
- Analytical Validation of Two Point-of-Care Assays for Hematological Analysis in the Miranda Donkey.Veterinary sciences · 2024Article
- Hemoglobin Determination: How Good is Good Enough?The Journal of nutrition · 2024Article
- Article
- Improving Anemia Assessment in Clinical and Public Health Settings.The Journal of nutrition · 2023Article
- Diagnosing anemia: Challenges selecting methods, addressing underlying causes, and implementing actions at the public health level.Annals of the New York Academy of Sciences · 2023Review
- Comparison of Anemia Screening Methods Using Paired Venous Samples in Women of Reproductive Age in Southern India.The Journal of nutrition · 2023Observational
- Risk factors of stunting and wasting in Somali pre-school age children: results from the 2019 Somalia micronutrient survey.BMC public health · 2022Article
- Article
- Serum zinc status is a matter of concern among children and non-pregnant women in a nationwide survey of Nepal.Scientific reports · 2021Article
- Agreement between dried blood spots and HemoCue in Tamil Nadu, India.Scientific reports · 2021Article
- Comparing hemoglobin distributions between population-based surveys matched by country and time.BMC public health · 2020Article
- Hemoglobin point-of-care testing in rural Gambia: Comparing accuracy of HemoCue and Aptus with an automated hematology analyzer.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn field studies, hemoglobin (Hb) is often measured using a battery-operated, portable HemoCue® hemoglobinometer.
methodsWe compared the performance of 2 HemoCue® models (Hb-201+ and Hb-301) and investigated effects of preanalytical factors on Hb results by simulating unfavorable field conditions.
resultsThe Hb-301 produced 2.6% higher results compared to the Hb-201+. Hb had to be measured within 1min of filling the Hb-301 cuvette to avoid artificially elevated concentrations (1.3% per min). The Hb-301 cuvettes withstood elevated temperature (37°C) and humidity (72%) for 3weeks, while the Hb-201+ cuvettes degraded within 10min under those conditions. Both cuvette types withstood elevated temperature for 3weeks. Properly-collected venous and capillary blood produced comparable results. Pooled capillary blood produced comparable results to the second and third but not the fourth drop of blood (3.3% lower). Blood could be stored for ≤4days at 10-30°C before Hb-201+ measurement, but only for 1day at 10-23°C before Hb-301 measurement (≤1% change in Hb).
conclusionsHigher Hb results obtained with the Hb-301 may influence the interpretation of anemia prevalence in health surveys. While the Hb-301 performed better in high humidity conditions, the Hb-201+ provided more user flexibility regarding delayed Hb reading.
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