Evidence map›Paper›PMID 28412225›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2017

Enhancing tissue permeability with MRI guided preclinical focused ultrasound system in rabbit muscle: From normal tissue to VX2 tumor.

Yao Sun, Xiaobing Xiong, Darpan Pandya, Youngkyoo Jung, Akiva Mintz, Satoru Hayasaka, Thaddeus J Wadas, King C P Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. HIFU-Driven Targeted Pyroptosis Therapy in Basal-Like Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yao SunDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Xiaobing XiongDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Darpan PandyaComprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Youngkyoo JungDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Akiva MintzDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: amintz@wakehealth.edu.
Satoru HayasakaDepartment of Psychology, The University of Texas at Austin, SEA 2.214, 108 E. Dean Keeton Stop A8000, Austin, TX 78712, USA.
Thaddeus J WadasDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
King C P LiCarle Illinois College of Medicine, University of Illinois at Urbana- Champaign, Urbana, IL 61801, USA. Electronic address: kingli@illinois.edu.
Wake Forest University · USThe University of Texas at Austin · USUniversity of Illinois Urbana-Champaign · US

Funding

Pulsed high intensity focused ultrasound facilitated drug deliveryR01EB009009 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LI, KING C. · 2008 to 2012
$2.0M
MR Guided Focused Ultrasound Controlled Stem Cell Therapy for Brain TumorR01CA184091 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LI, KING C. · 2014 to 2018
$1.6M
Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072NCI NIH HHS R01 CA184091NIBIB NIH HHS R01 EB009009
6 · The paper itself

Abstract

High Intensity Focused Ultrasound (HIFU) is an emerging noninvasive, nonionizing physical energy based modality to ablate solid tumors with high power, or increase local permeability in tissues/tumors in pulsed mode with relatively low power. Compared with traditional ablative HIFU, nondestructive pulsed HIFU (pHIFU) is present in the majority of novel applications recently developed for enhancing the delivery of drugs and genes. Previous studies have demonstrated the capability of pHIFU to change tissue local permeability for enhanced drug delivery in both mouse tumors and mouse muscle. Further study based on bulk tissues in large animals and clinical HIFU system revealed correlation between therapeutic effect and thermal parameters, which was absent in the previous mouse studies. In this study, we further investigated the relation between the therapeutic effect of pHIFU and thermal parameters in bulky normal muscle tissues based on a rabbit model and a preclinical HIFU system. Correlation between therapeutic effect and thermal parameters was confirmed in our study on the same bulk tissues although different HIFU systems were used. Following the study in bulky normal muscle tissues, we further created bulky tumor model with VX2 tumors implanted on both hind limbs of rabbits and investigated the feasibility to enhance tumor permeability in bulky VX2 tumors in a rabbit model using pHIFU technique. A radiolabeled peptidomimetic integrin antagonist,

Indexed as

Drug Delivery SystemsHigh-Intensity Focused Ultrasound AblationMuscle NeoplasmsAnimalsButtocksCoordination ComplexesFemaleHeterocyclic Compounds, 1-RingIndium RadioisotopesMagnetic Resonance ImagingPermeabilityRabbitsTomography, Emission-Computed, Single-PhotonCoordination ComplexesHeterocyclic Compounds, 1-Ringindium-111-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acidIndium Radioisotopes(111)In(111)In chloride (InCl(3)) (PubChem CID: 24,812)High intensity focused ultrasoundImage guided drug deliveryMRIRabbit modelSPECTTissue permeabilityTranslational studyVX2 tumor

Identifiers

PMID28412225
PMCPMC6047512
OpenAlexW2607184167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.