Evidence map›Paper›PMID 28412220›Full record

ArticleExperimental neurology2017

Inflammation-induced GluA1 trafficking and membrane insertion of Ca

G Wigerblad, J R Huie, H Z Yin, M Leinders, R A Pritchard, F J Koehrn, W-H Xiao, G J Bennett, R L Huganir, A R Ferguson and 3 more

Abstract read
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. The neuroimmune-glutamate hypothesis of addiction.Neuroscience and biobehavioral reviews · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

G WigerbladDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
J R HuieDepartment of Neurological Surgery, UC San Francisco, San Francisco, CA, USA.
H Z YinDepartment of Neurology, UC Irvine, Irvine, CA, USA.
M LeindersDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA.
R A PritchardDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA.
F J KoehrnDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA.
W-H XiaoDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA.
G J BennettDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA.
R L HuganirDepartment of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA.
A R FergusonDepartment of Neurological Surgery, UC San Francisco, San Francisco, CA, USA.
J H WeissDepartment of Neurology, UC Irvine, Irvine, CA, USA.
C I SvenssonDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
L S SorkinDepartment of Anesthesiology, UC San Diego, La Jolla, CA, USA. Electronic address: lsorkin@ucsd.edu.
University of California, San Diego · USKarolinska Institutet · SEUniversity of California, Irvine · USHoward Hughes Medical Institute · USNeurological Surgery · USUniversity of California, San Francisco · US

Funding

Maladaptive Plasticity in Spinal Cord Injury: Cellular MechanismsR01NS088475 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2015 to 2019
$1.7M
Spinal TNF elicits AMPAr trafficking and hyperalgesiaR01NS067459 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SORKIN, LINDA S · 2010 to 2014
$1.6M
NINDS NIH HHS R01 NS067459NINDS NIH HHS R01 NS088475
6 · The paper itself

Abstract

Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCalciumCarrageenanCyclic AMP-Dependent Protein KinasesDisease Models, AnimalEnzyme InhibitorsEtanerceptFemaleMaleMicePhosphatidylinositol 3-KinasesPosterior Horn CellsProtein TransportRadiculopathyRats, Sprague-DawleyAnti-Inflammatory Agents, Non-SteroidalCalciumCarrageenanCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsEtanerceptPhosphatidylinositol 3-KinasesReceptors, AMPASynaptophysinTumor Necrosis Factor-alphaAMPADorsal hornInflammatory painNMDAPI3KPKAReceptor trafficking

Identifiers

PMID28412220
PMCPMC5539914
OpenAlexW2607249536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.