Evidence map›Paper›PMID 28412168›Full record

ReviewMolecular therapy : the journal of the American Society of Gene Therapy2017

Facilitating Translational Nanomedicine via Predictive Safety Assessment.

Vahid Mirshafiee, Wen Jiang, Bingbing Sun, Xiang Wang, Tian Xia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Current approaches for safer design of engineered nanomaterials.Ecotoxicology and environmental safety · 2018
    Review
  14. Article
  15. Article
  16. Nanoparticle Technology: Having Impact, but Needing Further Optimization.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vahid MirshafieeCenter for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Wen JiangCenter for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Bingbing SunDivision of NanoMedicine, Department of Medicine, University of California Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, USA; State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, 2 Linggong Rd., Dalian 116024, China.
Xiang WangCenter for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Tian XiaCenter for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA; Division of NanoMedicine, Department of Medicine, University of California Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, USA; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: txia@ucla.edu.

Funding

Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the LungR01ES016746 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS · 2008 to 2017
$3.4M
Toxicological Profiling of Engineered Nanomaterials (ENMs) in the MPS (RES)U01ES027237 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEL, ANDRE ELIAS, XIA, TIAN · 2016 to 2020
$2.2M
Carbon Nanotube Structure-Activity Relationships for Predictive ToxicologyR01ES022698 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HERSAM, MARK C., NEL, ANDRE ELIAS · 2014 to 2018
$2.1M
NIEHS NIH HHS R01 ES016746NIEHS NIH HHS R01 ES022698NIEHS NIH HHS U01 ES027237
6 · The paper itself

Abstract

Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano-based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsBacterial InfectionsDrug Administration RoutesDrug Evaluation, PreclinicalHumansInflammationNanostructuresNeoplasmsPatient SafetyQuantum DotsStructure-Activity RelationshipTheranostic NanomedicineTissue EngineeringTranslational Research, BiomedicalAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic Agentsadverse outcome pathway (AOP)engineered nanomaterial (ENM)nanomedicinenanosafetypredictive toxicologysafer designstructure-activity relationship (SAR)

Identifiers

PMID28412168
PMCPMC5498808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.