ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Disconnection of the Perirhinal and Postrhinal Cortices Impairs Recognition of Objects in Context But Not Contextual Fear Conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Internal connectivity of the mouse mesocortical ring and functional implications.Brain structure & function · 2026Article
- A matter of complexity? The role of the dorsal posterior parietal cortex in processing changes in spatial information across time.Behavioral neuroscience · 2025Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Lateral entorhinal cortex lesions impair odor-context associative memory in male rats.Journal of neuroscience research · 2022Article
- Dual projecting cells linking thalamic and cortical communication routes between the medial prefrontal cortex and hippocampus.Neurobiology of learning and memory · 2022Article
- Beyond the hippocampus: The role of parahippocampal-prefrontal communication in context-modulated behavior.Neurobiology of learning and memory · 2021Review
- Multi-level analyses of associative recognition memory: the whole is greater than the sum of its parts.Current opinion in behavioral sciences · 2020Review
- Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.Brain pathology (Zurich, Switzerland) · 2020Article
- A Conditioning-Strengthened Circuit From CA1 of Dorsal Hippocampus to Basolateral Amygdala Participates in Morphine-Withdrawal Memory Retrieval.Frontiers in neuroscience · 2020Article
- Involvement of the Postrhinal and Perirhinal Cortices in Microscale and Macroscale Visuospatial Information Encoding.Frontiers in behavioral neuroscience · 2020Article
- CA1-projecting subiculum neurons facilitate object-place learning.Nature neuroscience · 2019Article
- Prefrontal connections of the perirhinal and postrhinal cortices in the rat.Behavioural brain research · 2018Article
- Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.Trends in neurosciences · 2018Review
- Impaired discrimination with intact crossmodal association in aged rats: A dissociation of perirhinal cortical-dependent behaviors.Behavioral neuroscience · 2018Article
- Article
- Integration of objects and space in perception and memory.Nature neuroscience · 2017Review
- Jamais vu all over again.Nature neuroscience · 2017Article
- Putting objects in context: A prefrontal-hippocampal-perirhinal cortex network.Brain and neuroscience advancesArticle
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (POR), homolog to the parahippocampal cortex in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat POR relies on object information received from the PER to form complex representations of context. Using three fear-conditioning (FC) paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3D and 2D objects), we examined the effects of crossed excitotoxic lesions to the POR and the contralateral PER. Performance of rats with crossed lesions was compared with that of rats with ipsilateral POR plus PER lesions and sham-operated rats. We found that rats with contralateral PER-POR lesions were impaired in object-context recognition but not in contextual FC. Therefore, interaction between the POR and PER is necessary for context-guided exploratory behavior but not for associating fear with context. Our results provide evidence for the hypothesis that the POR relies on object and pattern information from the PER to encode representations of context. The association of fear with a context, however, may be supported by alternate cortical and/or subcortical pathways when PER-POR interaction is not available. Our results suggest that contextual FC may represent a special case of context-guided behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.