ArticleThe Journal of biological chemistry2017
2-Alkylquinolone alkaloid biosynthesis in the medicinal plant
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Biosynthesis of barley wax β-diketones: a type-III polyketide synthase condensing two fatty acyl units.Nature communications · 2023Article
- Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood.Journal of natural medicines · 2023Review
- Transcriptome and metabolome profiling of the medicinal plantFrontiers in genetics · 2023Article
- Functional characterization of key polyketide synthases by integrated metabolome and transcriptome analysis on curcuminoid biosynthesis inSynthetic and systems biotechnology · 2022Article
- Suspect screening and targeted analysis of acyl coenzyme A thioesters in bacterial cultures using a high-resolution tribrid mass spectrometer.Analytical and bioanalytical chemistry · 2021Article
- An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides.Frontiers in plant science · 2021Review
- Enzymatic synthesis of 2-hydroxy-4RSC advances · 2020Article
- How structural subtleties lead to molecular diversity for the type III polyketide synthases.The Journal of biological chemistry · 2019Review
- New Insights on Cyclization Specificity of Fungal Type III Polyketide Synthase, PKSIIIIndian journal of microbiology · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2-Alkylquinolone (2AQ) alkaloids are pharmaceutically and biologically important natural products produced by both bacteria and plants, with a wide range of biological effects, including antibacterial, cytotoxic, anticholinesterase, and quorum-sensing signaling activities. These diverse activities and 2AQ occurrence in vastly different phyla have raised much interest in the biosynthesis pathways leading to their production. Previous studies in plants have suggested that type III polyketide synthases (PKSs) might be involved in 2AQ biosynthesis, but this hypothesis is untested. To this end, we cloned two novel type III PKSs, alkyldiketide-CoA synthase (ADS) and alkylquinolone synthase (AQS), from the 2AQ-producing medicinal plant,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.