ArticleNeuroImage2017
The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- A systematic review of the relationship between magnetic resonance imaging based resting-state and structural networks in the rodent brain.Frontiers in neuroscience · 2023Pooled it
- Dynamic structural connectivity changes in cortical and cortico-striatal strokes in mice.Neural regeneration research · 2026Article
- Relaxation-weighted MRI analysis of biofilm EPS: Differentiating biopolymers, cells, and water.Biofilm · 2024Article
- Charting cortical-layer specific area boundaries using Gibbs' ringing attenuated T1w/T2w-FLAIR myelin MRI.bioRxiv : the preprint server for biology · 2024Article
- Quantum dipole interactions and transient hydrogen bond orientation order in cells, cellular membranes and myelin sheath: Implications for MRI signal relaxation, anisotropy, and TMagnetic resonance in medicine · 2024Article
- Revealing the MRI-Contrast in Optically Cleared Brains.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- In vivo disentanglement of diffusion frequency-dependence, tensor shape, and relaxation using multidimensional MRI.Human brain mapping · 2024Article
- Datasets assessing lipid-content in optically cleared brains.Data in brief · 2024Article
- Structural projections to the nucleus accumbens link to impulsive components of human risk preference.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A comprehensive protocol for quantitative magnetic resonance imaging of the brain at 3 Tesla.PloS one · 2024Article
- Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum.Schizophrenia bulletin · 2023Article
- Article
- Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI.eLife · 2023Article
- Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces.Magnetic resonance letters · 2023Article
- In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis.eLife · 2023Article
- Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia.BMC psychiatry · 2023Article
- Article
- White matter microstructure and longitudinal relaxation time anisotropy in human brain at 3 and 7 T.NMR in biomedicine · 2023Article
- Review
- Brain tract structure predicts relapse to stimulant drug use.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Despite the widespread use of magnetic resonance imaging (MRI) of the brain, the relative contribution of different biological components (e.g. lipids and proteins) to structural MRI contrasts (e.g., T1, T2, T2*, proton density, diffusion) remains incompletely understood. This limitation can undermine the interpretation of clinical MRI and hinder the development of new contrast mechanisms. Here, we determine the respective contribution of lipids and proteins to MRI contrast by removing lipids and preserving proteins in mouse brains using CLARITY. We monitor the temporal dynamics of tissue clearance via NMR spectroscopy, protein assays and optical emission spectroscopy. MRI of cleared brain tissue showed: 1) minimal contrast on standard MRI sequences; 2) increased relaxation times; and 3) diffusion rates close to free water. We conclude that lipids, present in myelin and membranes, are a dominant source of MRI contrast in brain tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.