Evidence map›Paper›PMID 28410977›Full record

ArticleMethods (San Diego, Calif.)2017

Intravital imaging of the kidney.

Takashi Hato, Seth Winfree, Pierre C Dagher

Abstract read
In one paragraph

Article in Methods (San Diego, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Indiana O'Brien Center for Advanced Renal Microscopic Analysis.American journal of physiology. Renal physiology · 2021
    Review
  5. Review
  6. Review
  7. Intravital Imaging Techniques for Biomedical and Clinical Research.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020
    Review
  8. Article
  9. Review
  10. Article
  11. Renal Interstitial Platelet-Derived Growth Factor Receptor-Journal of the American Society of Nephrology : JASN · 2018
    Article
  12. Imaging IGF-I uptake in growth plate cartilage using in vivo multiphoton microscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Takashi HatoDepartment of Medicine, Indiana University, Indianapolis, IN, United States. Electronic address: thato@iu.edu.
Seth WinfreeDepartment of Medicine, Indiana University, Indianapolis, IN, United States.
Pierre C DagherDepartment of Medicine, Indiana University, Indianapolis, IN, United States; Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN, United States; Roudebush Indianapolis Veterans Affairs Medical Center, Indianapolis, IN, United States. Electronic address: pdaghe2@iupui.edu.
Indiana University – Purdue University Indianapolis · USRichard L. Roudebush VA Medical Center · US

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
PROBE DELIVERY COREP30DK079312 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2007 to 2021
$17.1M
Pilot--Using Zebrafish Model of Pronephros DevelopmentP50DK061594 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2002 to 2006
$5.3M
Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury.R01DK107623 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Pierre C Dagher · 2016 to 2026
$4.4M
Indiana Clinical and Translational Sciences InstituteKL2TR001106 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$3.2M
Modifying kidney injury through p53 signaling.R01DK099345 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAGHER, PIERRE C, SUTTON, TIMOTHY ALAN · 2014 to 2017
$1.4M
Modulating purine metabolism to treat kidney injury in sepsis.K08DK113223 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI HATO, TAKASHI · 2017 to 2021
$757k
Protective pathways in sepsis-induced renal injuryI01BX002901 · VA · RLR VA MEDICAL CENTER · PI Takashi Hato · 2016 to 2026
–
BLRD VA I01 BX002901NCATS NIH HHS KL2 TR001106NIDDK NIH HHS K08 DK113223NIDDK NIH HHS P30 DK079312NIDDK NIH HHS P30 DK097512NIDDK NIH HHS P50 DK061594NIDDK NIH HHS R01 DK099345NIDDK NIH HHS R01 DK107623
6 · The paper itself

Abstract

Two-photon intravital microscopy is a powerful tool that allows the examination of dynamic cellular processes in the live animal with unprecedented resolution. Indeed, it offers the ability to address unique biological questions that may not be solved by other means. While two-photon intravital microscopy has been successfully applied to study many organs, the kidney presents its own unique challenges that need to be overcome in order to optimize and validate imaging data. For kidney imaging, the complexity of renal architecture and salient autofluorescence merit special considerations as these elements directly impact image acquisition and data interpretation. Here, using illustrative cases, we provide practical guides and discuss issues that may arise during two-photon live imaging of the rodent kidney.

Indexed as

Fluorescent DyesAnimalsIntravital MicroscopyKidneyMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, Fluorescence, MultiphotonTime-Lapse ImagingFluorescent Dyes

Identifiers

PMID28410977
PMCPMC5600698
OpenAlexW2606907166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.