Evidence map›Paper›PMID 28410896›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2017

White Paper AGA: Gastroparesis: Clinical and Regulatory Insights for Clinical Trials.

Pankaj J Pasricha, Michael Camilleri, William L Hasler, Henry P Parkman

2 registry-linked trialsAbstract readConference ProceedingsConsensus Statement
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05846802 recruitingnot on this mapstarted 2024, after this paper: background citation

Gastroparesis Registry 4 (GpR4): Improving the Understanding of Gastroparesis and Functional Dyspepsia

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2024 to 2027Enrolled250ConditionsGastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus Type I, Gastroparesis Due to Diabetes Mellitus Type II
NCT05981300 recruitingnot on this mapstarted 2024, after this paper: background citation

GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis

Typeobservational_patient_registrySponsorJohns Hopkins Bloomberg School of Public HealthRan2024 to 2027Enrolled216ConditionsGastroparesis, Gastroparesis-like Syndrome
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Review
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  7. Review
  8. Role of Endoscopy in Motility Disorders of Upper Gastrointestinal Tract.Journal of neurogastroenterology and motility · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Baseline Predictors of Longitudinal Changes in Symptom Severity and Quality of Life in Patients With Suspected Gastroparesis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Observational
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pankaj J PasrichaJohns Hopkins Center for Neurogastroenterology, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: ppasric1@jhmi.edu.
Michael CamilleriClinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
William L HaslerDivision of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
Henry P ParkmanGastroenterology Section, Temple University School of Medicine, Philadelphia, Pennsylvania.

Funding

Physiological Characterization and Data Integration CoreP01DK068055 · NIDDK · MAYO CLINIC ROCHESTER · PI FARRUGIA, GIANRICO · 2004 to 2019
$23.8M
Temple University Gastroparesis Clinical CenterU01DK073975 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI HENRY PAUL PARKMAN · 2006 to 2026
$7.4M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
Visceral Afferent Dysfunction in Diabetic GastropathyU01DK073985 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HASLER, WILLIAM L · 2006 to 2015
$2.7M
NIDDK NIH HHS P01 DK068055NIDDK NIH HHS U01 DK073975NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01 DK073985
6 · The paper itself

Abstract

Gastroparesis continues to represent a large unmet clinical need and a major opportunity for new drug development. This has led to increasing interest by federal funding agencies, regulatory bodies, and industry. This article summarizes the proceedings of the gastroparesis section of the "Drug Development Conference: Clinical Endpoints in Upper GI Disorders" organized by the American Gastroenterological Association in Washington, DC, on October 27-28, 2016. The presentation, diagnosis, and current therapeutic strategies are briefly reviewed, followed by a detailed discussion of the regulatory strategy, recommended endpoints, and future directions.

Indexed as

Clinical Trials as TopicGastrointestinal AgentsGastroparesisHumansGastrointestinal AgentsClinical Trial DesignEndpointsGastroparesis

Identifiers

PMID28410896
PMCPMC6642744

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.