Evidence map›Paper›PMID 28410812›Full record

ArticleVaccine2017

CD4

Robert E Sealy, Sherri L Surman, Julia L Hurwitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Robert E SealyDepartment of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Sherri L SurmanDepartment of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Julia L HurwitzDepartment of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: julia.hurwitz@stjude.org.
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Influence of maternal antibodies on a Sendai virus-vectored RSV vaccineR01AI088729 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DEVINCENZO, JOHN P., HURWITZ, JULIA L · 2010 to 2014
$3.0M
NCI NIH HHS P30 CA021765NIAID NIH HHS R01 AI088729
6 · The paper itself

Abstract

The RSV vaccine field suffered a major set-back when children were vaccinated with a formalin-inactivated RSV vaccine (FI-RSV). Unexpectedly, the vaccinated children fared worse than unvaccinated children when they were naturally infected with RSV. Mouse models were then developed that implicated the CD4

Indexed as

Adoptive TransferAnimalsAntibody-Producing CellsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleImmunity, MucosalImmunoglobulin AImmunoglobulin GMice, Inbred BALB CMice, NudeRespiratory Syncytial Virus InfectionsRespiratory SystemRespiratory Tract InfectionsSerumImmunoglobulin AImmunoglobulin GAntibody secreting cellsCD4(+) T cellsRespiratory syncytial virusRisk-benefitT helper function

Identifiers

PMID28410812
PMCPMC5588898
OpenAlexW2605569463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.