Evidence map›Paper›PMID 28410760›Full record

Trial reportThe Journal of hospital infection2017

Deconstructing the relative benefits of a universal glove and gown intervention on MRSA acquisition.

A D Harris, D J Morgan, L Pineles, E N Perencevich, S L Barnes

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of hospital infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Controlling an Outbreak of Multidrug-resistantJournal of Korean medical science · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

A D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: aharris@epi.umaryland.edu.
D J MorganDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA; Veterans Affairs Maryland Healthcare System, Baltimore, MD, USA; Center for Disease Dynamics, Economics and Policy, Washington, DC, USA.
L PinelesDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
E N PerencevichUniversity of Iowa Health Care, Iowa City, IA, USA.
S L BarnesRobert H. Smith School of Business, University of Maryland, College Park, MD, USA.
University of Maryland, Baltimore · USCenter for Disease Dynamics, Economics & Policy · USUniversity of Iowa Health Care · USUniversity of Maryland, College Park · US

Funding

K24 Clinical Research in Antimicrobial Resistance and Hospital EpidemiologyK24AI079040 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRIS, ANTHONY D · 2009 to 2018
$1.8M
Does Universal Glove and Gown use decrease carbapenem-resistant Gram-negative bacteriaR18HS024045 · AHRQ · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRIS, ANTHONY D · 2015 to 2017
$1.2M
AHRQ HHS R18 HS024045NIAID NIH HHS K24 AI079040
6 · The paper itself

Abstract

backgroundThe 20-site Benefits of Universal Glove and Gown (BUGG) study found that wearing gloves and gowns for all patient contacts in the intensive care unit (ICU) reduced acquisition rates of meticillin-resistant Staphylococcus aureus (MRSA). The relative importance of gloves and gowns as a barrier, improved hand hygiene, and reduced healthcare worker (HCW)-patient contact rates is unknown.

aimTo determine what proportion of the reduction in acquisition rates observed in the BUGG study was due to improved hand hygiene, reduced contact rates, and universal glove and gown use using agent-based simulation modelling.

methodsAn existing agent-based model to simulate MRSA transmission dynamics in an ICU was modified, and the model was calibrated using site-specific data. Model validation was completed using data collected in the BUGG study. A full 2

findingsAcross 40 simulated replications for each factorial design point and intervention site, approximately 44% of the decrease in MRSA acquisition rates was due to universal glove and gown use, 38.1% of the decrease was due to improvement in hand hygiene compliance on exiting patient rooms, and 14.5% of the decrease was due to the reduction in HCW-patient contact rates.

conclusionUsing mathematical modelling, the decrease in MRSA acquisition in the BUGG study was found to be due primarily to the barrier effects of gowns and gloves, followed by improved hand hygiene and lower HCW-patient contact rates.

Indexed as

Cross InfectionDrug Resistance, MicrobialDrug Resistance, MultipleGloves, ProtectiveHand DisinfectionHealth PersonnelHumansInfection ControlIntensive Care UnitsMethicillin-Resistant Staphylococcus aureusModels, TheoreticalProtective ClothingVancomycin ResistanceContact precautionsContact ratesHand hygieneMathematical modellingMulti-drug-resistant organismsRandomized controlled trial

Identifiers

PMID28410760
PMCPMC6839451
OpenAlexW2596540757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.