ReviewSeminars in nephrology2017
Timing of Dialysis Initiation: What Has Changed Since IDEAL?
Review in Seminars in nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Trial
- Trends in chronic dialysis practices and outcomes in North American children: a 30-year NAPRTCS registry analysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Inflammatory markers predict MIA syndrome progression and cardiovascular disease outcomes in maintenance dialysis patients.BMC nephrology · 2025Article
- Knowledge, attitudes, and practice toward sarcopenia among maintenance dialysis patients in Anhui, China.BMC public health · 2025Article
- Early Versus Late Initiation of Dialysis in CKD Stage 5: Time for a Consensus.Kidney international reports · 2025Review
- Personalized nutritional management in the transition from non-dialysis dependent chronic kidney disease to dialysis.Kidney research and clinical practice · 2024Article
- Adequacy of haemodialysis and associated factors among patients with end-stage kidney disease in Tanzania.Journal of Taibah University Medical Sciences · 2024Article
- The error of estimated GFR in predialysis care.Scientific reports · 2024Article
- Smoking and coronary artery disease risk in patients with diabetes: A Mendelian randomization study.Frontiers in immunology · 2023Article
- Use of Wearable and Wireless Technology in Real-World Clinical Settings to Improve Patient Outcomes in Chronic Kidney Disease: A Mixed Methods Pilot Prospective Trial.Canadian journal of kidney health and disease · 2023Article
- The neutrophil-to-lymphocyte ratio may indicate when to start hemodialysis.Renal failure · 2022Article
- Does delivering more dialysis improve clinical outcomes? What randomized controlled trials have shown.Journal of nephrology · 2022Review
- Chronic hemodialysis: Evaluation of dialysis adequacy and mortality.Annals of medicine and surgery (2012) · 2022Article
- The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study.Nutrition journal · 2021Article
- Implication of Trends in Timing of Dialysis Initiation for Incidence of End-stage Kidney Disease.JAMA internal medicine · 2020Article
- Article
- Should we abandon GFR in the decision to initiate chronic dialysis?Pediatric nephrology (Berlin, Germany) · 2020Review
- Quality of life improved for patients after starting dialysis but is impaired, initially, for their partners: a multi-centre, longitudinal study.BMC nephrology · 2020Article
- Intradialytic Nutrition and Hemodialysis Prescriptions: A Personalized Stepwise Approach.Nutrients · 2020Review
- Systematic Survey of Creatinine-Based Versus Cystatin C-based Estimated GFR in People with Diabetes.HCA healthcare journal of medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The optimal timing of initiation of maintenance dialysis in patients with end-stage renal disease currently is unknown. This transition period is one of exceptionally high vulnerability for patients; annual mortality rates in stage 5 chronic kidney disease through the first year of maintenance dialysis exceed 20%. The results of the Initiating Dialysis Early and Late (IDEAL) study, a randomized trial that tested the impact of dialysis initiation at two different levels of kidney function on outcomes, showed no significant difference in survival or other patient-centered outcomes between treatment groups. These data have challenged the established paradigm of using estimates of glomerular filtration as the primary guide for initiation of maintenance dialysis and illustrate the compelling need for research to optimize the high-risk transition period from chronic kidney disease to end-stage renal disease. This article reviews the findings of the IDEAL study and summarizes the evolution of research findings, updated clinical practice guidelines, and trends in dialysis initiation practices in the United States in the 6 years since the publication of the results from IDEAL. Complementary strategies to the use of estimated glomerular filtration rate to optimally time the initiation of maintenance dialysis and potentially improve patient-centered outcomes also are considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.