ReviewPediatric rheumatology online journal2017
Lung involvement in childhood onset granulomatosis with polyangiitis.
Review in Pediatric rheumatology online journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- A Case Report of Granulomatosis with Polyangiitis Presenting with Chronic Conjunctivitis.Journal of education & teaching in emergency medicine · 2026Article
- Granulomatosis With Polyangiitis Presenting as Deep Vein Thrombosis in an Adolescent: A Rare Case Report.Clinical case reports · 2026Article
- An atypical case of granulomatosis with polyangiitis in a 15-year-old girl presenting with pyoderma gangrenosum-like ulcers on the face.Dermatology online journal · 2025Article
- Respiratory manifestations of pediatric granulomatosis with polyangiitis: A 12-year experience from a tertiary care facility.Pediatric pulmonology · 2025Article
- Pediatric Granulomatosis With Polyangiitis: A Case Report Compared to a Case Review in the Last 10 Years.Cureus · 2025Article
- Pediatric Presentations of Granulomatosis With Polyangiitis: A Double Case Study.Case reports in dermatological medicine · 2025Article
- Endobronchial vasculitis in childhood granulomatosis with polyangiitis.Respirology case reports · 2021Article
- Granulomatosis with Polyangiitis in Adolescence: Two Distinct Presentations.Case reports in rheumatology · 2021Article
- Article
- Pulmonary manifestations of systemic vasculitis in childhood.Breathe (Sheffield, England) · 2020Article
- Coughing up clues: 16-year-old girl with acute haemoptysis.BMJ case reports · 2020Article
- Onset of granulomatosis with polyangiitis obscured by heart disease in an elderly man.Radiology case reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulomatosis with polyangiitis is an ANCA-associated systemic vasculitis with a low incidence in the pediatric population. Lung involvement is a common manifestation in children affected by granulomatosis with polyangiitis, both at disease's onset and during flares. Its severity is variable, ranging from asymptomatic pulmonary lesions to dramatic life-threatening clinical presentations such as diffuse alveolar haemorrhage. Several radiologic findings have been described, but the most frequent abnormalities detected are nodular lesions and fixed infiltrates. Interstitial involvement, pleural disease and pulmonary embolism are less common. Histology may show necrotizing or granulomatous vasculitis of small arteries and veins of the lung, but since typical features may be patchy, the site for lung biopsy should be carefully chosen with the help of imaging techniques such as computed tomography. Bronchoalveolar lavage is helpful to confirm the diagnosis of alveolar haemorrhage. Pulmonary function tests are frequently altered, showing a reduction in the diffusion capacity for carbon monoxide, which can be associated with obstructive abnormalities related to airway stenosis. Nodular lung lesions tend to regress with immunosuppressive therapy, but lung disease may also require second line treatments such as plasmapheresis. In cases of massive diffuse alveolar haemorrhage, ventilator support is crucial in the management of the patient.
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