Evidence map›Paper›PMID 28410586›Full record

SynthesisBMC complementary and alternative medicine2017

Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients.

Yan Sun, Jinping Zhang, Yuanyuan Chen

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yan SunDepartment of Chinese Medicine, Nankai Hospital, No. 6 Changjiang Road, Nankai District, Tianjin, 300100, China. nkyysy@sina.com.
Jinping ZhangDepartment of Chinese Medicine, Nankai Hospital, No. 6 Changjiang Road, Nankai District, Tianjin, 300100, China.
Yuanyuan ChenDepartment of Pharmacy, Affiliated Hospital of Logistics Institute of Chinese Armed Police Force, Tianjin, 300163, China.
Tianjin Nankai Hospital · CNLogistics University of People's Armed Police Force · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers.

methodsStudies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews. Extracted data included the total effective rate, helicobacter pylori eradication rates, recurrence rate, and adverse reaction rate. Fifty-eight randomised controlled trials involving 5192 patients were included in the final analysis.

resultsResults showed that Jianzhong decoction therapy was more effective than conventional Western medicine therapy (total effective rate, odds ratio [OR] = 4.29, 95% confidence interval [CI]: 3.51-5.23, P = 0.000; helicobacter pylori eradication rates, OR =2.10, 95% CI: 1.69-2.61, P = 0.000; recurrence rate, OR =0.23, 95% CI: 0.18-0.29, P = 0.000; and adverse reaction rate, OR =0.20, 95% CI: 0.12-0.33, P = 0.000).

conclusionsJianzhong decoction increased the total effective rate and helicobacter pylori eradication rate, and lowered the recurrence and adverse reaction rates. The results of this study can be used as a guide for clinical treatment of peptic ulcers.

Indexed as

PhytotherapyAdolescentAdultAnti-Ulcer AgentsDrugs, Chinese HerbalDuodenal UlcerFemaleHelicobacter InfectionsHelicobacter pyloriHumansMaleStomach UlcerAnti-Ulcer AgentsDrugs, Chinese HerbalJianzhong decoctionMeta-analysisPeptic ulcerRandomised controlled trials

Identifiers

PMID28410586
PMCPMC5391578
OpenAlexW2607461916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.