ArticleBMC plant biology2017
A candidate RxLR effector from Plasmopara viticola can elicit immune responses in Nicotiana benthamiana.
Article in BMC plant biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 52 citations in OpenAlex.
- Review of the Pathogenic Mechanism of Grape Downy Mildew (Microorganisms · 2025Review
- Functional Analysis of KPvRxLR27, a Novel Plasmopara viticola Effector from a Korean Isolate, and Its Role in Hypersensitive Response.The plant pathology journal · 2025Article
- Characterization of the CBM50 Gene Family inJournal of fungi (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Analysis of Gene Family of Carbohydrate-Binding Modules inInternational journal of molecular sciences · 2024Article
- A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68.Nature communications · 2024Article
- The pathogenicity of Plasmopara viticola: a review of evolutionary dynamics, infection strategies and effector molecules.BMC plant biology · 2024Review
- A Novel EffectorJournal of fungi (Basel, Switzerland) · 2023Article
- A pathogenesis-related protein 1 of Cucurbita moschata responds to powdery mildew infection.Frontiers in genetics · 2023Article
- Functional analysis of the Nep1-like proteins fromPlant signaling & behavior · 2022Article
- Functional Analyses of a Small Secreted Cysteine-Rich Protein ThSCSP_14 inInternational journal of molecular sciences · 2022Article
- ThSCSP_12: Novel Effector inInternational journal of molecular sciences · 2022Article
- A Putative Effector LtCSEP1 fromPlants (Basel, Switzerland) · 2022Article
- Article
- Identification and characterization of putative effectors fromFrontiers in plant science · 2022Article
- "Core" RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?Virulence · 2021Article
- Importin-αs are required for the nuclear localization and function of the Plasmopara viticola effector PvAVH53.Horticulture research · 2021Article
- Article
- Plasmopara viticola effector PvRXLR111 stabilizes VvWRKY40 to promote virulence.Molecular plant pathology · 2021Article
- An RXLR effector PlAvh142 from Peronophythora litchii triggers plant cell death and contributes to virulence.Molecular plant pathology · 2020Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiverse plant pathogens deliver effectors into plant cells to alter host processes. Oomycete pathogen encodes a large number of putative RxLR effectors which are likely to play a role in manipulating plant defense responses. The secretome of Plasmopara viticola (downy mildew of grapevine) contains at least 162 candidate RxLR effectors discovered in our recent studies, but their roles in infection and pathogenicity remain to be determined. Here, we characterize in depth one of the putative RxLR effectors, PvRxLR16, which has been reported to induce cell death in Nicotiana benthamiana in our previous study.
resultsThe nuclear localization, W/Y/L motifs, and a putative N-glycosylation site in C-terminal of PvRxLR16 were essential for cell death-inducing activity. Suppressor of G-two allele of Skp1 (SGT1), heat shock protein 90 (HSP90) and required for Mla12 resistance (RAR1), but not somatic embryogenesis receptor-like kinase (SERK3), were required for the cell death response triggered by PvRxLR16 in N. benthamiana. Some mitogen-activated protein kinases and transcription factors were also involved in the perception of PvRxLR16 by N. benthamiana. PvRxLR16 could also significantly enhance plant resistance to Phytophthora capsici and the nuclear localization was required for this ability. However, some other PvRxLR effectors could suppress defense responses and disease resistance induced by PvRxLR16, suggesting that it may not trigger host cell death or immune responses during physiological infection under natural conditions.
conclusionThese data demonstrate that PvRxLR16 may be recognized by endogenous proteins in nucleus to trigger immune responses in N. benthamiana, which in turn can be suppressed by other PvRxLR effectors.
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