Evidence map›Paper›PMID 28410573›Full record

SynthesisBMC pediatrics2017

Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies.

Noor Samuels, Rob A van de Graaf, Rogier C J de Jonge, Irwin K M Reiss, Marijn J Vermeulen

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 18 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 18 syntheses or guidelines pooled it, 299 citations in OpenAlex.

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  11. Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
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  16. Early full enteral feeding for preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Noor SamuelsDepartment of Pediatrics, Division of Neonatology, Erasmus MC, Room SH-3005, P.O. Box 2060, 3015, CN, Rotterdam, The Netherlands.
Rob A van de GraafDepartment of Pediatrics, Division of Neonatology, Erasmus MC, Room SH-3005, P.O. Box 2060, 3015, CN, Rotterdam, The Netherlands.
Rogier C J de JongeDepartment of Pediatrics, Division of Neonatology, Erasmus MC, Room SH-3005, P.O. Box 2060, 3015, CN, Rotterdam, The Netherlands.
Irwin K M ReissDepartment of Pediatrics, Division of Neonatology, Erasmus MC, Room SH-3005, P.O. Box 2060, 3015, CN, Rotterdam, The Netherlands.
Marijn J VermeulenDepartment of Pediatrics, Division of Neonatology, Erasmus MC, Room SH-3005, P.O. Box 2060, 3015, CN, Rotterdam, The Netherlands. m.j.vermeulen@erasmusmc.nl.
Erasmus MC · NLErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is a severe multifactorial disease in preterm neonates associated with high morbidity and mortality. Better insight into prognostic values of the many reported factors associated with NEC is needed to enable identification of neonates at risk for NEC. The aim was to systematically review the literature to identify independent risk factors for NEC from the literature.

methodsMedline, Cochrane, Embase, Pubmed and Google Scholar were searched systematically for cohort studies reporting prognostic factors for NEC in neonates using multivariable analysis. Studies were scored with the Quality In Prognosis Studies tool (QUIPS).

resultsFrom 5154 initial hits, 14 prognostic studies were included, with various designs. Study quality was rated high in three studies, moderate or low in the 11 others. Significant prognostic factors for NEC reported in at least two studies were: low birth weight, small for gestational age, low gestational age, assisted ventilation, premature rupture of membranes, black ethnicity, sepsis, outborn, hypotension (all increased risk), surfactant therapy (conflicting results) and cesarean section (lower risk). Meta-analysis was considered not feasible.

conclusionHigh quality studies on prognostic factors for NEC are rare. Several prognostic factors, that are not necessarily causal, are associated with NEC. High quality prognostic research is necessary to establish the predictive values of these factors.

Indexed as

Enterocolitis, NecrotizingHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesPrognosisRisk Factorsepidemiologyintestinal perforationnecrotizing enterocolitisneonatal intensive care unitpretermprognosisrisk factors

Identifiers

PMID28410573
PMCPMC5391569
OpenAlexW2606166834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.